“highly significant”

Gender and age Even after exclusion of sex-linked genes, gender was independently associated with the largest number of expression traits ( n = 31) which, considered all together, contributed to a highly significant discrimination between males and females ( P <10 −100 ).

When p was below the calculation limits of the software (highly significant) we noted p<1.0e−99*.

http://www.ncbi.nlm.nih.gov/geo/ ) data base indicates a highly significant anti-correlation with a gene signature obtained from primary human lung fibroblast treated with dithiothreitol (DTT) for 24 hours (Overlapping P = 1.7E-99) [ 63 ]; and a significant correlation with a gene set from dexamethasone-treated (24 hours) human primary osteoblast-like cells (HOb)(GEO series GSE10311 .Overlapping P = 1.0E-46).

The SNP-based heritability estimated on the observed scale was 0.78% (SE = 0.04%), which was highly significant (Z = 21.09, P-value = 9.41 × 10−99), further supporting a polygenic basis for ovarian cancer.

TH interneuron density increased steeply toward ventral caudoputamen ( β = 519.7, p = 5.6 × 10 −85 , N (hemispheres) = 13, N (sections) = 299), while SST interneurons showed a more moderate but highly significant ventral increase ( β = 253.9, p = 3.9 × 10 −98 , N (hemispheres) = 12, N (sections) = 276).

Additionally, the chi-square test for taxonomic distribution differences was highly significant ( χ 2 = 549.60, p < 7.64E-97), indicating that microbial composition varies between conditions.

The Caucasian GRS showed a strong and highly significant association with RA in UKRAG (OR = 2.87, 95% CI 2.60 to 3.17, P = 2.7 × 10 -96 ) when all UKRAG cases and controls were incorporated in the analysis.

We also observed a highly significant difference in the expression variation between lincRNA probes and probes mapping to protein-coding transcripts (Wilcoxon Mann Whitney P<3.85×10 −96 ).

We did not find a significant sex difference in overall PRS effects (OR male = 4.70 (4.16–5.31), OR female = 5.28 (4.80–5.80), P difference = 0.141, two-sample two-sided Z -test), even though the effect of sex was highly significant (OR = 2.54 (2.33–2.78), P = 1.93 × 10 −94 , one-sample two-sided Z -test).

The correlation between deltaSVM and effect-size for the 579 SNPs within 100 bp of a DHS is highly significant, with a Pearson correlation coefficient C = 0.721 (t-distribution P = 7.68e-94) ( Fig. 2c ).

Two highly significant loci associated with idiopathic MN were discovered: the human leukocyte antigen (HLA)-DQ alpha chain 1 ( HLA-DQA1 ) locus (rs 2187668; odds ratio, 4.32; P = 8.0 × 10 −93 ) and the PLA2R1 locus (rs 4664308; odds ratio, 2.28; P = 8.6 × 10 −29 ).

Approximately 1,000 of the inducible genes had an iDHS within 150 kb of the TSS, and nearly 500 of these elements were located within just 25 kb which was highly significant ( P = 10 −92 ) (Fig 4 E), further signifying a role for the iDHSs as inducible enhancers of these genes.

One-way ANOVA revealed highly significant differences in abundance, with 10 metabolites showing strong accumulation patterns (F-values 1.38 × 1031−7.84 × 1032; p < 1.03 × 10−92, FDR-corrected).

Association analysis The SNP AC000158: g.1390292G>A , within intron 3 showed a highly significant association with the polled genotype (χ 2 =423, -log 10 P=91.85) ( Table 1 Figure 1) and perfect co-segregation in all 443 Holsteins.

Importantly, 64 of the 126 genes were also repressed when Miz1 and Arf were coexpressed, identifying a highly significant overlap in target genes (P = 2.5 × 10 −92 ) and defining a core program of genes that are jointly repressed by Myc and Miz1 in the presence of Arf ( Fig. 6 b ).

ActiveDriver identifies N-terminal mutations in five cancer types as highly significant ( n = 73, FDR p = 2.5e − 92 from ActiveDriver; Fig. 2b ), confirming constitutive activation of CTNNB1 via disrupted phosphorylation as a prevalent driving mechanism of cancer.

We also showed confirmed association with AGA at AR gene by highly significant signal spanning the gene region (OR = 2.20, 95% CI = 2.04–2.37, p = 2.40×10 −91 for risk allele T of top SNP rs2497938).

On the other hand, there were 180 genes differentially regulated by both dfoxo and Xbp1 s overexpression in the fat body ( Figure 4 C) and this overlap was highly significant ( p < 10 −90 ).

Homologous motif prediction using the MEME Suite (v5.5.9) identified four highly significant conserved motifs ( p < 1 × 10 −90 ) in human WEE2 and its family kinases.

Conversely, when looking for enriched features for mRNA-only eQTLs (26131) we find that insulator in between is the only highly significant regulatory feature ( P ≈ 9.47e−90).

These overlaps are very unlikely to occur by random chance, as even the protein pair with least common probesets has a highly significant P -value ( MCM5 and MCM6 , 47 common probesets, P < 10 -87 ).

The association of CDS Htz1 peaks with AS transcripts, although lower than the association of 3' Htz1 peaks with AS transcripts (Figure 3 D), is highly significant ( p = 1.6 x 10-87; Fisher’s exact test).

Comparing synchronized neurons with a fixed I-E delay of 5 ms, we observed a highly significant correlation (r = 0.99, P<3.1x10 -87 , Spearman Correlation, Fig. 4b ) between the excitatory input strength and the Rayleigh statistic, the criterion we used to measure the statistical significance of stimulus-synchronization.

A Mann–Whitney U test confirmed the difference was highly significant ( U = 130,876, p < 1e-86, Cohen’s d = 2.05), indicating a large effect size.

The three participant-specific tests revealed highly significant deviations from the uniform distribution (PA: χ2(7, N = 189) = 421.50, p = 10 -86 ; PB: χ2(7, N = 94) = 107.36, p = 10 -19 ; PC: χ2(7, N = 126) = 512.73, p = 10 -105 ).