“highly significant”

SNPs near APOE gave highly significant results (e.g., rs2075650, p = 3.2×10 −81 ), but no other genome-wide significant evidence for association was obtained in the full sample.

Results Monocyte responsiveness to LPS showed a highly significant, negative correlation with blood pressure levels (ρ< -0.4; P<10 -80 ).

Indeed, both tumour types showed highly significant retention of intron 8 sequences in association with rs700635[C] ( P = 8.3 × 10 −80 and 1.4 × 10 −34 for breast and prostate tumours, respectively; Supplementary Material, Fig.

In the whole dataset, eight highly significant recombination breakpoints were identified in the genomes of the four variants cited above ( p -values < 10 −79 , Table 4 ).

Statistical Significance of Circuit Category Effects One-way ANOVA on proof generation times across the seven non-ECDSA circuits reveals highly significant differences ( F = 355.0 , p < 10 − 79 ), with circuit type explaining 94.1% of variance ( η 2 = 0.941 ).

There was a highly significant overlap (p=1.2 × 10 -79 , n=113) between the differentially expressed genes from the two tissue types, indicating that the tissues respond to oncogenic Ras with both common and tissue-specific transcriptional responses.

As shown in Table 1 , the PGF levels are higher in the Denmark sample (median ± interquartile range, sd: 15.9±4.9 in Denmark vs 12.2±4.7 in Cilento) and the difference is highly significant (p = 3.9×10 −79 ) (see Figure 2 ), as assessed with a multivariate analysis taking into account the effect of age, sex, menstruation, and smoking and using the Cilento age-matched sample.

Furthermore, the overlap in hits between cell lines was highly significant ( p < 1e-78, hypergeometric test; Figure 3G ).

This result is highly significant, with P-value<10 −77 ; this p-value is calculated based on 10,000-time permutation evaluating the possibility that 66 out of 83 randomly selected regions overlap or contain with CpG island.

As additional validation supporting the role of myeloid-derived cells, and specifically monocytes, as a dominant contributor to plasma CyC levels, we found a significant positive correlation between blood monocyte counts and CyC residual in the UKB cohort ( Figure S4 B; multivariate regression), and two-sample Mendelian randomization using blood-derived CST3 eQTLs (eQTLGen 58 ) as exposure identified a highly significant positive association with CyC production (p = 6.13e−77; Figure 4 E).

Results for the theta band showed a highly significant association between the mean relevance of each brain region, and how their centrality changes in association with p-tau231 levels (rho = 0.499; p = 9.2 × 10 –77 ).

Similarly, the results revealed a strong positive correlation between RA Factor and disease severity, with Spearman’s ρ = 0.902 and a highly significant P -value < 3.9 × 10 −76 ).

The Pearson correlation of individual question scores for the same participant was r = 0.19, which was highly significant with p = 7e-75 (n = 9520).

We performed reduced representation bisulfite sequencing (RRBS), 5 a technology for interrogating hundreds of thousands of methylation sites with digital precision 27 , 28 on the rat PNS and found characteristic and highly significant patterns relating gene methylation and activity (p≈1.0x10 −74 ) that differed markedly between LCP and HCP genes.

The results clearly show an overall highly significant increase in the number of such events in TA MSI clones compared to TA MSS malignant clones ( p -value < 2 × 10 −74 ).

T2D status was found to be a highly significant predictor of weight loss efficacy ( P = 2.0 × 10 −73 ; Supplementary Table 4 ), with an average predicted reduction of 2.87 percentage points in BMI loss for people with a T2D diagnosis.

The test was highly significant ( p = 6.77 × 10 −72 ), indicating that the data were not missing completely at random (MCAR).

As depicted in figure 2 , the overrepresentation of children of Sub-Saharan African descent across the higher quintiles of the BMD-GS was highly significant in both studies (Generation R: P = 2.7 × 10 − 71 and BMDCS, P = 2.3 × 10 − 70 ).

Lola-N binds to 1,369 genes (false discovery rate [FDR] < 0.1%) that show a highly significant overlap (p < 6 × 10 −71 ) with the 836 genes (FDR < 0.1%) bound by Prospero.

However, the effect of sex is highly significant ( p = 2.62 × 10 −70 ).

A highly significant statistical analysis ( p = 1.14×10 −69 ), also in agreement with its experimental counterpart, further supported the evidence for gradient directed migration of the MV3 melanoma cells inside the virtual chamber.

Furthermore, we determined that approximately one-third of the Nup98-bound genes derived from CHIP Seq analysis in Drosophila cells that have mouse orthologs were FoxK1 bound and regulated ( 30 , 39 ), which is highly significant ( P = 1.85754E–69) (see Fig.

In the GSE14520 cohort, risk scores showed a trending stage-dependent increase from nontumor tissues to early-stage HCC (BCLC 0/A) and more advanced HCC stages (BCLC B–C), with highly significant differences across all groups (overall p =1.86×10 −69 ; Fig. 5A ).

The ChIP-seq targets of Cbf11 and Cbf12, on the other hand, showed a highly significant overlap (71 shared genes, p = 4 × 10 −69 ).

The overlaps with plasma were 47 (T1∩plasma) and 54 (M1∩plasma), both highly significant after Bonferroni correction (Fisher’s exact test p < 10−68 and p < 10−74; Supplementary Fig. 2a ), supporting the reliability of the plasma-derived ground truth.