“highly significant”

The model was highly significant ( p < 0.0001), and the global performance of the test is explained by the area under the ROC curve, which is equals to 0.84 (95% CI).

This difference was highly significant during ages 4–9 years ( p < .0001), with the largest cluster volume (664 mm 3 ) in the left parahippocampal gyrus at age 9 years.

Compared to the manual approach of biometric data export and intraocular lens calculation (76.7 ± 12.3 s) as well as the manual export of the reference image to a portable external storage device (26.8 ± 5.5 s), a highly significant saving of time was achieved ( p < 0.0001).

alocis exhibited a highly significant association with HbA1c (r = 0.80; p < 0.0001), reinforcing its dependence on metabolic dysregulation, whereas P. gingivalis demonstrated moderate positive correlations with both PPD (r = 0.38; p = 0.04) and CAL (r = 0.38; p = 0.04), reflecting its role in progressive tissue destruction, alongside a persistent correlation with HbA1c (r = 0.57; p = 0.001).

The analysis revealed that the Blanc treatment positively improved tooth brightness across all three experiments, with a highly significant effect ( p < 0.0001).

Restricting the analysis to the five populations sampled within Ryder Bay, global F st was lower (0.0181) but still highly significant ( P <0.0001), indicating the presence of fine-scale population genetic structuring.

For qPCR validation, we selected genes representing different functional categories within the WGCNA red module: (1) TIMP1—the hub gene identified by machine learning; (2) HCLS1 and C5AR1—two of the five candidate genes with known immune regulatory functions; (3) THBS4 (Thrombospondin 4)—although not among the final five candidate genes, THBS4 was a highly significant DEG (log2FC = 8.36, p < 0.0001) within the red module with established roles in extracellular matrix remodeling and cardiac fibrosis ( 28 ).

A highly significant difference in overall survival (OS) was detected between high- and low-risk groups ( P < 0.0001) as shown in Fig. 6 b.

In both cases, the differences between the genotypes are highly significant (accelerated: P <0.0001; rocking: P <0.0001, two-way ANOVA).

Every time point's t -test reveals highly significant differences (all p < 0.0001), suggesting that FBS levels alter significantly over the course of the follow-up.

Figure 2a , depicts a marked difference in the diestrus phase duration within the DMPA-treated group before and after administration, showing a highly significant difference ( p <0.0001).

For the awake group, there was a highly significant difference ( P < 0.0001) in all brain regions between the test–retest and the memantine-challenge conditions.

Results from ANOVA indicated highly significant effects for time ( p ≤0.0001), genotype ( p ≤0.05) and their interaction ( p ≤0.0001) ( Supplementary data for Fig. 2 ).

Variance analyses (data not shown) confirmed great variability among RILs shown by highly significant values of F tests (F value 3.9, 2.4 and 1.82, p <0.0001 for dry and wet seasons and greenhouse experiments, respectively).

Changing the patient selection, of course, resulted in highly significant outcome changes: Women undergoing fresh cycles now were, suddenly, significantly younger ( P = 0.0001) (previously significantly older) in the complete autologous group ( P < 0.0001) and significant differences in AMH and FSH to the benefit of frozen cycles completely disappeared, together with all prior outcome advantages in pregnancy rates for frozen cycles ( P = 0.0086 before and P = 0.0451 after adjustment for age and AMH).

In the former case, this difference was very highly significant: 10.64 in controls (MOM estimator) vs. 7.43 in ADHD (Test statistic = 3.22, p < 0.0001), while in the latter, it was not significant: 10.13 vs. 8.13, respectively for control and ADHD groups (Test statistic = 1.99, p = 0.103) ( Fig. 4 ).

These differences were highly significant ( P < 0.0001).

A particularly prominent PNUTS staining was seen in cancers with PTEN (10q23) and 12p deletions, which was highly significant in all, ERG-negative, and ERG-positive cancers ( p < 0.0001 each). 3.5.

Mixing was a relatively sensitive method of detecting the most highly significant changes (p < 0.0001) (86% of changes detected), however it was not very specific; as many as one third of gene expression changes showing p < 0.05 in mixed samples were not confirmed by individual profiles.

Moreover, the study revealed a highly significant correlation between SNOT-12 and SNOT-22 ( P = .0001).

Each of these differences in the functional composition of the sets of paralogs and unduplicated genes were statistically highly significant (p < 0.0001, χ 2 test).

The agreement for the category “motives of crime” was highly significant (Cohen’s K was 0.92, p < 0.0001; 95% CI = − 0.036–0.101), as it was for the category “contentiousness” (Cohen’s K was 0.90, p < 0.0001; 95% CI = − 0.084–0.123) and for the category “overkilling” (Cohen’s K was 0.81, p < 0.0001; 95% CI = − 0.075–0.180) suggesting, according to Viera and Garrett [ 71 ] and to McHugh [ 72 ], a substantial interrater agreement coefficient for all of these variables.

A two-way ANOVA showed a highly significant effect of RVT ( p < 0.0001).

The extraction temperature ( X 2 ) and time ( X 3 ) showed a highly significant impact on the extracted amount of rhein because of their p -values of <0.0001.

Correlation analysis between SPR and ACM illuminance measurements (in lux) for visible light ( Table 1 ) resulted to be strong ( r = 0.946) and highly significant ( p < 0.0001) with a slope of 0.558.