“highly significant”

Segregation analysis gave a highly significant association between the C allele and disease (p = 1.8×10 −42 ).

We found a highly significant correlation between both measurements in plasma samples, as shown in Fig. 1 a ( p = 2.6 × 10 −42 , r 2 = 0.902).

This difference was highly significant (Kruskal–Wallis χ2=185.15, P =3.64×10−42; Wilcoxon BH-adjusted P =3.66×10−42) ( Fig. 4b ).

4C , NMI and DRAM1 show a highly significant correlative expression with correlation coefficient (CC) of 0.71 and p < 3.7e-042.

Furthermore, there was a weak but highly significant negative correlation between the number of paralogs for a gene and its d N /d S ratio compared with orthologs (Spearman’s rank: r s = −0.131, P = 4.33 × 10 −42 ), suggesting that genes that are retained as paralogs tend to be under stronger purifying selection.

There is also a mild but highly significant correlation between the total number of targets involved in a combination and percentile of cell lines in which it is synergistic (Spearman’s ρ = 0.21, P = 6.25 × 10 −42 ), (Fig. 6A ).

The neighboring gene Pearson correlations were also found to be highly significant ( C. dubliniensis/C. albicans Pearson correlation = 0.218, p = 6.4 × 10 -42 ; C. tropicalis/C. dubliniensis Pearson correlation = 0.103, p = 9.8 × 10 -10 ).

Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 × 10 −42 , odds ratio 1.33 [95% confidence interval [CI] = 1.29–1.37]) and telomere length (p = 2.84 × 10 −14 , odds ratio 0.85 [95% CI = 0.81–0.89]).

A t-test comparison at TSS for the random sample and the origin peaks demonstrated a highly significant difference (p<10 −41 , Fig.

IPA identified a highly significant network ( p < 10 −41 ) containing 20 of the 64 (31%) input genes and 15 bridging genes ( Figure 2 ).

This result is highly significant (p=10 –41 , exact ranks test, MATLAB signrank ) and holds for all tested pitch classes in the pair ([0,3,6,9], Figure 4D ).

The water-sensitive Predictive model ( P w ) was the winning model, outperforming the second best model, the water-sensitive Reactive model ( R w ), by a highly significant 95 log likelihood units ( χ 2 (2) = 190, p < 10 −41 ).

This difference is statistically highly significant (p = 1.2 10 -41 ; Chi-square test with 1 degree of freedom).

Chi-square tests yielded the most highly significant results for terpenoids ( p = 1.2 × 10 −41 ), amino acids and derivatives ( p = 1.6 × 10 −35 ), flavonoids ( p = 3.1 × 10 −33 ), lipids ( p = 4.8 × 10 −15 ), flavonols ( p = 1.8 × 10 −12 ), phenolic acids ( p = 2.6 × 10 −12 ), and flavones ( p = 1.1 × 10 −11 ). 3.2.

Although Aβ and tau oligomer levels showed a highly significant correlation (Spearman r = .541, p = 2.7 × 10 −41 ), no increase of tau oligomer levels regarding the disease stage was observed (Figure 1B ).

cerevisiae proteasome genes, the enrichment of genes containing the known Rpn4p binding site was highly significant (GGTGGCAA; p < 6 × 10 –41 ).

A highly significant association was found between the two tests ( p = 6.09 × 10 −41 ).

When normalized, manual analysis accuracy for N-T tissues increased from 0.75 to 0.91, which was highly significant (p=7,72x10 -41 ).

Notably, dipeptides, such as Val-Glu and Met-Gln, showed highly significant values in AP ( p -value > 10 −40 ) ( Figure 3 ).

In Family A, SNPs on chr-4 at physical locations 62,076,809 bp and 62,076,876 bp exhibited the strongest association; additional highly significant SNPs (−log 10 p >40) clustered between 60,613,763 bp and the end of chr-4.

The difference among three genotypes was highly significant both in males (p < 1E-40) and females (p = 1E-33).

The 6 most highly significant smoking CpGs were also the most highly associated with bladder cancer (smoking p -value < 10 - 40 , bladder cancer p -value < 10 - 10 ).

All correlations are highly significant (p < 1.0E-40).

Other miRNAs were not ranked at the top 30 of comparative activity mode (Methods), however they show highly significant differential activity (corrected WRS p -value < 1 e −40) and substantial activity in at least one of the populations (activity p -values below 1 e − 4 among at least third of cells in at least one population).

The PSs for TG (30 SNPs), LDL-C (28 SNPs), and HDL-C (60 SNPs) explained a relatively small, but highly significant, proportion of the variance (5.6 % [F = 157, P = 1.7 × 10 −40 ], 3.1 % [F = 99, P = 6.2 × 10 −27 ] and 5.1 % [F = 164, P = 1.1 × 10 −36 ]; Additional file 6 ) and were not associated with confounders (Additional file 7 ) with the exception of the HDL-C PS, which was associated with confounder neutrophil counts ( P value = 1.8 × 10 −2 ).