“highly significant”

Circulating T cell fraction remained highly significant after adjusting for clinical factors in the pan-cancer cohort (Fig. 5b (HR = 0.76, P = 2.6 × 10 −46 ) and Extended Data Fig. 9a ) and within five individual cancer types after multiple hypothesis correction—head and neck squamous cell carcinoma (HR = 0.70, adjusted P = 4.68 × 10 −2 ), pancreatic adenocarcinoma (HR = 0.74, adjusted P = 4.81 × 10 −2 ), colon adenocarcinoma (HR = 0.85, adjusted P = 1.12 × 10 − 2 ), lung adenocarcinoma (HR = 0.80, adjusted P = 5.4 × 10 −3 ) and sarcoma (HR = 0.68, adjusted P = 1.57 × 10 −4 ).

A highly significant association was observed between BMI and triglyceride levels (Beta = 0.26, p = 3.06E-46), and a positive correlation trend was also seen between BMI and UA.

These represent 41% and 33% of upregulated phosphoproteins in OCMI91s and OVCAR8 cells, respectively - a highly significant overlap by hypergeometric test (enrichment 3.0-fold; p = 4x10 -46 ).

The ANN achieved an F-statistic value of 432.7, indicating a highly significant model fit with a practically negligible probability of F-statistic ( p < 6.06 × 10 −46 ).

5 E) demonstrates highly significant segregation of GBMs and LGGs ( P <10 –45 , odds ratio=28, Fisher exact test) supporting that YAP activation is a hallmark of malignant brain cancer and suggesting that this eight-gene signature might provide sufficient information to distinguish high-grade from low-grade gliomas.

Of note, a highly significant association (− log 10 P = 44.79) for ‘seed: colouration with phenol’ on chromosome 2A was just 0.37 Mb from the Ppo-A1 gene known to control discolouration in wheat food products.

Three transcription factors were highly significant; MYCN (p-value = 1.71E-45), MYC (p-value = 1.11E-11) and NFE2L2 (p-value = 5.97E-17) during this analysis.

Analysis using the GEPIA database revealed a highly significant correlation ( p = 2e -45 , R = 0.82) between these markers, providing new insights into the molecular mechanisms underlying PAAD progression and identifying new targets for diagnostic and therapeutic strategies.

briggsae strains revealed a highly significant effect of both strain ( P = 2.2×10 −45 ) and generation ( P = 5.9×10 −9 ) – see Table 2 .

The paired change was highly significant (McNemar’s χ 2 (1) = 198.89, p < 3.65 × 10 −45 ) ( Figure 4 ).

MMP14 exhibited a marked increase in expression in tumor tissues, with a highly significant difference between normal and cancer groups ( p = 4.9 × 10 −45 ).

Among 11 prototypical sarcomere genes, 10 displayed highly significant isoform shifts (p = 5.23 × 10 −45 –2.89 × 10 −200 ).

A chi‐square test confirmed that this enrichment was highly significant ( p = 1.1357 × 10 −44 ), underscoring the prominent role of DNA transposons in gene regulation.

Another highly significant but non-genic SNP coincides with a selection candidate region (e.g., Figure 3C ) covering the KIT and KDR (P = 2.46e-44) loci.

A highly significant overall association between PRS and COVID-19 infection was shown for the White ethnic group ( p = 8.69 × 10 –44 , < 0.0001).

A total of 18 SDRs were identified across the genetic maps, primarily located on LG1–LG4, LG6, and LG8, with LG8 and LG3 containing 5 and 4 SDRs respectively, Strong collinearity between the genetic map and physical assembly was confirmed by highly significant Pearson correlations (R = −0.84 to 0.83; P = 10 −43 to 10 −217 ) for marker positions across all nine chromosomes ( Table S9 ; Fig.

Subsequent memory effects in selective neurons Due to the preceding screening procedure, we found highly significant fractions of neurons responding selectively to one or more items in all recorded brain regions (all P < 10 –43 , binomial test, one-sided with n = total number of neurons per region, k = number of responsive neurons per region, P = 0.001, corresponding to the alpha level of our response criterion, refer to “item responses”, Fig. 2 , Fig.

26 , 28 - 31 A subsequent meta-analysis, which included 5,159 patients with AIS and 17,840 controls, reported a highly significant association with this SNP, with a P = 1.22 × 10 -43 for both men and women, and an even stronger P = 2.94 × 10 -48 for women only. 32 The present study established a significant association between the LBX1 polymorphism rs11190870 and AIS susceptibility ( P < .001), consistent with prior research conducted across diverse populations, particularly in East Asian cohorts.

To compare our findings to a genetic variant with known association with neurodegenerative diseases and aging, we made similar analysis with the frequencies of APOE ε4 allele, which showed a highly significant decrease with age ( p = 3 × 10 −43 ).

This finding was highly significant (p = 4.5×10 −43 ).

Using various carbohydrate-deficient transferrin indices, and adjusting for alcohol intake, a recent GWAS isolated the highly significant independent effects of variants in the transferrin ( TF , P =5.5 × 10 −43 ), and phosphoglucomutase 1 ( PGM1 , P =2 × 10 −9 ) genes on carbohydrate-deficient transferrin. 126 Neuroimaging phenotypes Neuroimaging outcomes are promising new endophenotypes for addiction.

The concordance between SomaModules and the optimal WGCNA clustering is highly significant (Fisher’s exact test p -value = 10 –42 ).

The difference between the observed T:B conjugate rate, and that predicted to arise by chance, was highly significant at up to P = 10 -42 .

The top TB network was highly significant (p = 10 −42 ) and included 20 focus genes implicated in susceptibility to Mycobacteria tuberculosis infection in a 35 gene network ( Table 1 , Fig 4 ).

Although this overlap is highly significant ( P < 1.66e −42 ) it shows that even within the same species larger differences in genes detected to be bound by FoxP3 can be expected either due to the experimental design like cell lines or stimulation or due to genetic and biologic variance.