“highly significant”

Category II SNPs (SNPs with less functional evidence than Category I) also showed highly significant enrichment for low P-values (fold enrichment 1.42; P = 2.60e-40) ( Table 3 ).

We found a large (n = 98) and highly significant (p = 2.8e−40) overlap between the splicing events regulated by QKI and RBFOX2 ( Figure 4 D).

Intima-Media Thickness and Genetic OAG Risk First, we validated the association between the OAG-GRS and OAG, which was highly significant ( P = 4.8 * 10 −40 ), with an OR of 2.44 (95% CI = 2.13–2.78) for each standard deviation increase in OAG-GRS.

The difference in fit of the 13 models was highly significant ( p = 8 × 10 −40 , ANOVA), but there was no significant difference in the fits of the five top models, all of which incorporated a perseverative learning mechanism: Perseveration/Reward-learning model (PR model, ref. 36 ); differential forgetting Q -learning 33 ; ideal observer with perseveration (see Methods); ideal-observer Bayesian filters with perseveration for either a generic probabilistic reversal-learning task (see Methods), or a generic drifting reward probability task 37 .

In continuous light, there was a highly significant correlation between sister cell generation times ( R = 0.87, P < 1 × 10 –39 , Fig. 4c ), suggesting that the observed variation in generation times across all cells was not entirely stochastic.

A highly significant reduction ( p = 2.3 × 10 –39 ) in the number of Candida colonies was observed in the treatment arm when comparing pre- and post-study results.

falciparum ’s large proteins displayed unique and parasite-specific annotations, with a highly significant presence of host cell binding functions ( P = 3.21e−39) compared to the rest of the proteome.

S4b ), we found a highly significant peak on chromosome 17 (Fig. 6a , Supplementary Data 5 and 6 ) where the lead variant was an intergenic SNP upstream of the BMP2 gene (chr17:15643342:C>T, P = 3.45 × 10 − 39 ).

Remarkably, 35 insertions are located at common insertion sites (CISs), a highly significant result (Fisher's exact test p = 7.4×10 −39 ) ( Table 1 ).

These results were corroborated by the analysis of functional pathways using the ConsensusPathDB 25 (Methods); gene sets showed highly significant overlaps ( P <7.66 × 10 −39 –2.38 × 10 −05 ) with pathways involving OR and GPCR-related signalling and signal transduction, (extra-cellular matrix related) processes of inter-cellular communication, immunoregulatory processes and membrane-linked drug transport.

4c ) show that the TE and ICM nuclei in blastocyst embryos have highly significant differences in the mean nuclear dry mass density ( p -value = 8.11e−39), while the differences for cleavage state embryos are nonsignificant ( p -value = 0.0105).

To further investigate the significance of these directional findings we estimated the differences in the slopes using z-scores and demonstrated that for 31 of the 35 genes the differences were highly significant (Bonferroni corrected p<1×10 −38 ) ( Supplementary Table 4 ), thus strongly suggesting these were not chance observations.

Using a logistic regression model, we found that several factors had a highly significant influence on whether a proximal eQTL was detected as an aiQTL; namely, the distance of the eQTL from the TSS (P = 1 × 10 − 38 ), the number of samples with more than one allele-specifically mapped read (P = 1 × 10 − 88 ), the log P value of the eQTL (P = 3 × 10 − 174 ), the minor allele frequency of the eQTL (P = 2 × 10 − 44 ) and the median number of allele-specifically mapped reads (among samples with more than one allele-specifically mapped read; P = 0.008).

Interestingly, in a joint model where both rs970740 and rs6025 were used as covariates for predicting cg16548605 variability, the effect of rs970740 was highly significant (p = 1.05×10 −38 ) but that of rs6025 was not (p = 0.90).

Similarly, Table 4 reveals a highly significant effect of elevation height on PV efficiency (F = 134.21, p = 1.31 × 10– 38 .

GO enrichments for the lightgreen module are highly significant for “secretory granule” (p=2.14E-38), “secretory vesicle” (p=1.96E-36), and different specific neutrophils-associated terms such as “neutrophil activation involved in immune response” (p=1.04E-35), “neutrophil degranulation” (p=1.04E-35), “neutrophil activation” (p=2.00E-35), and “neutrophil mediated immunity” (p=2.64E-35).

We measured the relative abundance of the total ether-linked lipids and observed a highly significant elevation ( p -value = 2.94E-38) of total ether-linked lipids at 48 h post virus infection ( Figure 5C ).

While the small (∼5 nm) difference between the early and late S-phase distributions is statistically highly significant (Kolmogorov–Smirnov test, P = 3e-38), it is unlikely that, given the ∼30-nm standard deviation of the individual distributions, this difference has biological significance.

The ISR total change included 7259 patients and showed a highly significant trend in an F statistic versus constant model with F = 169, p = 3.13 e − 38.

Module detection followed by a meta-analysis on chronological age identified fifteen consistently coexpressed PPI modules associated with chronological age, including a highly significant module ( P = 3.5 × 10 −38 ) enriched for ‘ T-cell activation ’ marking age-associated shifts in lymphocyte blood cell counts ( R 2 = 0.603; P = 1.9 × 10 −10 ).

The most highly significant variant at 5q33.1 (rs17728338) shows opposing effects on AD and psoriasis (MNM p = 3.96 × 10 −38 ; Table S5 ) and lies 2 kb upstream of ANXA6 (MIM 114070 ) and 8 kb downstream of TNIP1 (MIM 607714 ).

A highly significant S-PrediXcan signal ( p = 6.10e–38) was also obtained for this WDR19 intron cluster in testis, however the evidence for colocalization with the GWAS peak was low (PP.H4.abf = 0.39).

We observed a highly significant correlation ( R 2 = 0.5086, p = 8.5e−38; data not shown).

The Jaccard similarity coefficients and the highly significant p -values (hypergeometric test p < 1 × 10 −37 in all cases) of the overlap of the top upregulated genes in DN and the GNs indicated that upregulated genes were common not only among FSGS, MN and IgAN, but also among DN and the three GNs ( Figure 1B ).

Examination of the proteins with reduced abundance in the sod-1 mutant showed a highly significant enrichment of ribosomal proteins ( p < 10 –37 ) including 24 RPL proteins, which are in the large 60S ribosomal subunit ( Figure 6 C, Table S6 ).