“highly significant”

The frequency of IL-21 producing Tfh cells were highly significant ( p < 0.0001) in patients with acute dengue when compared with healthy individuals, where hardly any cytokine production was observed (Fig. 2 d).

1 ) The Brown-Forsythe test performed to test homogeneity variance between groups was highly significant for a violation of an assumption of homogeneity (F = 49.77 (2, 1860), p < .0001).

39 Billerey and colleagues detected FGFR3 alterations in 27 (84%) out of 32 grade (G)1 NMIBCs, 16 (55%) out of 29 G2 tumors, and 5 (7%) of 71 G3 tumors, with a highly significant association ( p < 0.0001) between FGFR3 mutations and low-grade disease. 40 FGFR3 mutations have also been detected in around 10% of MIBCs. 41 , 42 The most frequent types of FGFR3 aberrations in UCs are activating mutations. 21 , 34 FGFR3S249C, the most common aberration (21%), induces ligand-inde

Statistical Inference Precision: The article reports highly significant p -values (e.g., p < 0.0001) from experiments with only three biological replicates per group.

From 4 h to 24 h, the cubic components were highly significant (R 2 = 0.985–0.990; p < 0.0001), with significant quadratic components from 4 h onwards ( p = 0.001–0.003).

The results are highly significant ( P < 0.0001), with a Type 1 match highly correlated with complete and partial metabolic responses while Type 2 and Type 3 matches are associated with no response/progression. 4.

In both the citalopram and pramipexole groups, the BDI score showed a highly significant decrease with a large effect size ( r ≥ 0.6) analyzed by a Wilcoxon signed-rank test ( Z = −4.018, P < 0.0001, and r = −0.877 for citalopram group and Z = −3.926, P < 0.0001, and r = −0.878 for pramipexole group).

Additional statistically highly significant decreases in activity were observed at position -17 (Mfe I, p < 0.0001) and +101 (Nar I, p < 0.0001) [Fig. 1C ].

In contrast, OS and EFS differences among patients with adenocarcinoma were highly significant (P<0.0001 and P<0.001, respectively).

Trend was highly significant for any HPV type, any high risk type, and low risk type, at p < 0.0001 for each, significant for HPV 16/18 at p = 0.0004 and HPV 16 at p = 0.0153, and not significant for HPV 18 at p = 0.2217.

There was a highly significant change in SBM frequency from baseline with elobixibat (10 mg and 15 mg) at Weeks 1 and 2 compared to placebo ( p < 0.0001) [ 44 ].

Results Analysis of Phenotypic Variation for Disease Severity at Seedling Stage The ANOVA results revealed highly significant variation ( P < 0.0001) for germplasm lines and pathotypes ( Table 1 ) while the genotype × year interaction effect was found to be non-significant.

In the analysis of variation among the frequencies in each ear alone, we noticed that it was highly significant (p<0.0001-t Student test) in all the frequencies for both the right and the left ears.

Sedation under ketamine and alfaxalone remained highly significant from control throughout physiological monitoring (P1: ketamine, 12 min:13.0±2.4, P <0.0001; alfaxalone, 11 min: 10.6±1.8, P = 0.0002; P2: ketamine, 19 min: 13.5±2.6, P <0.0001; alfaxalone, 16 min: 10.9±2.6, P = 0.0005); and animals under ketamine remained highly sedated upon returning to cage (28 min: 12.7±2.4, P <0.0001), whereas sedation under alfaxalone reduced more rapidly toward conscious levels (22 min: 8.6±2.7, P = 0.0059).

A retrospective analysis using this model enabled highly significant differentiation between peptide and non-peptide receptor families (logistic regression; p value < 0.0001).

Nevertheless, important differences in plasma cytokine levels were observed in HAT patients as compared to endemic, uninfected controls, with highly significant differences (p<0.0001) for IL1β, IL2, IL4, and IL10 and to a lesser extent for INFγ (p = 0.01).

The difference between the wild-type AV-T and AV-T Δ 1132 is highly significant at p < 0.0001 as determined by a Student’s two-tailed t test.

There was also a positive correlation between utrophin and β-DG levels in muscle fibres of DMD P11 (Spearman’s, r 2 = 0.75) and P12 (Pearson’s, r 2 = 0.45), both of which were highly significant (p<0.0001; Fig 4c and 4d ).

In terms of soil organic matter content, Wutai County had a significantly higher level (35.25 ± 4.20) compared to Pingshun County (26.65 ± 2.14), and this difference was statistically highly significant ( P < 0.0001).

The obtained mathematical model of TI was highly significant ( p -value < 0.0001).

The differences were highly significant ( P < 0.0001).

Geographical Differences in Skull Shape, Diversity and Size Highly significant shape differences ( p < 0.0001) were detected among all areas, except between Arctic localities (High Arctic vs.

Both the paramagnetic media concentration and the applied current led to highly significant changes in the levitation heights of live and dead cells ( P < 0.0001) ( Fig. 4 C ).

All three explanatory variables had a highly significant effect on survival ( P < 0.0001 in all cases).

Both main effects were also highly significant for Group: F(2, 228) = 52.02, p < 0.0001 (22.84% of variation) and Tissue region: F(2, 228) = 49.99, p < 0.0001 (21.95% of variation).