“highly significant”

There is also a mild but highly significant correlation between the total number of targets involved in a combination and percentile of cell lines in which it is synergistic (Spearman’s ρ = 0.21, P = 6.25 × 10 −42 ), (Fig. 6A ).

The neighboring gene Pearson correlations were also found to be highly significant ( C. dubliniensis/C. albicans Pearson correlation = 0.218, p = 6.4 × 10 -42 ; C. tropicalis/C. dubliniensis Pearson correlation = 0.103, p = 9.8 × 10 -10 ).

There were highly significant main effects for emotion (F (2,155) = 171.744, p = 7.4 × 10 −42 , η p 2 = 0.708), agency (F (1,71) = 630.212, p = 4.9 × 10 −37 , η p 2 = 0.899) and intentionality (F (1,71) = 11.799, p = 0.001, η p 2 = 0.143), regardless of serotonergic status, which supports task validity and suggests individuals were attuned to the social context of the scenarios.

Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 × 10 −42 , odds ratio 1.33 [95% confidence interval [CI] = 1.29–1.37]) and telomere length (p = 2.84 × 10 −14 , odds ratio 0.85 [95% CI = 0.81–0.89]).

A non-parametric test revealed that the difference was highly significant (Mann-Whitney, p = 9.2 × 10 −42 ).

This result is highly significant (p=10 –41 , exact ranks test, MATLAB signrank ) and holds for all tested pitch classes in the pair ([0,3,6,9], Figure 4D ).

IPA identified a highly significant network ( p < 10 −41 ) containing 20 of the 64 (31%) input genes and 15 bridging genes ( Figure 2 ).

The water-sensitive Predictive model ( P w ) was the winning model, outperforming the second best model, the water-sensitive Reactive model ( R w ), by a highly significant 95 log likelihood units ( χ 2 (2) = 190, p < 10 −41 ).

A t-test comparison at TSS for the random sample and the origin peaks demonstrated a highly significant difference (p<10 −41 , Fig.

Chi-square tests yielded the most highly significant results for terpenoids ( p = 1.2 × 10 −41 ), amino acids and derivatives ( p = 1.6 × 10 −35 ), flavonoids ( p = 3.1 × 10 −33 ), lipids ( p = 4.8 × 10 −15 ), flavonols ( p = 1.8 × 10 −12 ), phenolic acids ( p = 2.6 × 10 −12 ), and flavones ( p = 1.1 × 10 −11 ). 3.2.

This difference is statistically highly significant (p = 1.2 10 -41 ; Chi-square test with 1 degree of freedom).

The results of this hypergeometric distribution analysis verified a highly significant overlap of 39 ( P = 1.46e−41).

1 , 5 ) revealed a highly significant difference across all four groups of neurons (control SWA, lesioned SWA, control activated, lesioned activated; Kruskal–Wallis ANOVA, χ 2 = 211, p = 1.60e-41).

Although Aβ and tau oligomer levels showed a highly significant correlation (Spearman r = .541, p = 2.7 × 10 −41 ), no increase of tau oligomer levels regarding the disease stage was observed (Figure 1B ).

cerevisiae proteasome genes, the enrichment of genes containing the known Rpn4p binding site was highly significant (GGTGGCAA; p < 6 × 10 –41 ).

A highly significant association was found between the two tests ( p = 6.09 × 10 −41 ).

Sets of DEGs between treatments were partially overlapping and we observed that the intersection of genes that differed between PMD and controls regardless of LCL treatment was highly significant (probability density p<6.49e −41 , Figure 2A ).

When normalized, manual analysis accuracy for N-T tissues increased from 0.75 to 0.91, which was highly significant (p=7,72x10 -41 ).

All differences in the prevalence of deafness between each endpoint were highly significant with all p < 10 −40 .

(A) motifs that are highly significant (Benjamini-Hochberg corrected p < 10 −40 , odds ratio > 10) are listed here.

mikatae analyses were highly significant, with hypergeometric p -values < 10 -40 .

The SEA output includes an output ranking the proposed target/query interaction by probability (significant, p ≤ 10 –15 ; highly significant, p ≤ 10 –40 ) and by similarity score to an annotated compound/drug (Tanimoto coefficient, max Tc ≥ 0.40, max Tc 1.0 = exact match). 14 The SEA output ( Fig. 5 ) for our hit compounds was potentially informative in identifying additional potential targets for our most potent hit, niclosamide (KCNMA1 and TMPRSS4), as well as GSK-650394 (CAMKK2, AXL, RIPK1).

In Family A, SNPs on chr-4 at physical locations 62,076,809 bp and 62,076,876 bp exhibited the strongest association; additional highly significant SNPs (−log 10 p >40) clustered between 60,613,763 bp and the end of chr-4.

All correlations are highly significant (p < 1.0E-40).

Notably, dipeptides, such as Val-Glu and Met-Gln, showed highly significant values in AP ( p -value > 10 −40 ) ( Figure 3 ).