“highly significant”

This correlation was highly significant ( Fig 5B ; P value = 7.1x10 -39 ; linear regression), suggesting that the variation in additive effects of polymorphisms across the 20 environments, rather than the effect size, was associated with the changes in activity of interactions in the epistatic network.

Remarkably, 35 insertions are located at common insertion sites (CISs), a highly significant result (Fisher's exact test p = 7.4×10 −39 ) ( Table 1 ).

These results were corroborated by the analysis of functional pathways using the ConsensusPathDB 25 (Methods); gene sets showed highly significant overlaps ( P <7.66 × 10 −39 –2.38 × 10 −05 ) with pathways involving OR and GPCR-related signalling and signal transduction, (extra-cellular matrix related) processes of inter-cellular communication, immunoregulatory processes and membrane-linked drug transport.

there was a highly significant correlation between measurements of macrophage infiltration and SAMD9 expression in LGG ( Figure 7C ) (partial.cor = 0.551, p = 7.78E-39).

4c ) show that the TE and ICM nuclei in blastocyst embryos have highly significant differences in the mean nuclear dry mass density ( p -value = 8.11e−39), while the differences for cleavage state embryos are nonsignificant ( p -value = 0.0105).

To further investigate the significance of these directional findings we estimated the differences in the slopes using z-scores and demonstrated that for 31 of the 35 genes the differences were highly significant (Bonferroni corrected p<1×10 −38 ) ( Supplementary Table 4 ), thus strongly suggesting these were not chance observations.

Using a logistic regression model, we found that several factors had a highly significant influence on whether a proximal eQTL was detected as an aiQTL; namely, the distance of the eQTL from the TSS (P = 1 × 10 − 38 ), the number of samples with more than one allele-specifically mapped read (P = 1 × 10 − 88 ), the log P value of the eQTL (P = 3 × 10 − 174 ), the minor allele frequency of the eQTL (P = 2 × 10 − 44 ) and the median number of allele-specifically mapped reads (among samples with more than one allele-specifically mapped read; P = 0.008).

Interestingly, in a joint model where both rs970740 and rs6025 were used as covariates for predicting cg16548605 variability, the effect of rs970740 was highly significant (p = 1.05×10 −38 ) but that of rs6025 was not (p = 0.90).

Similarly, Table 4 reveals a highly significant effect of elevation height on PV efficiency (F = 134.21, p = 1.31 × 10– 38 .

GO enrichments for the lightgreen module are highly significant for “secretory granule” (p=2.14E-38), “secretory vesicle” (p=1.96E-36), and different specific neutrophils-associated terms such as “neutrophil activation involved in immune response” (p=1.04E-35), “neutrophil degranulation” (p=1.04E-35), “neutrophil activation” (p=2.00E-35), and “neutrophil mediated immunity” (p=2.64E-35).

We measured the relative abundance of the total ether-linked lipids and observed a highly significant elevation ( p -value = 2.94E-38) of total ether-linked lipids at 48 h post virus infection ( Figure 5C ).

While the small (∼5 nm) difference between the early and late S-phase distributions is statistically highly significant (Kolmogorov–Smirnov test, P = 3e-38), it is unlikely that, given the ∼30-nm standard deviation of the individual distributions, this difference has biological significance.

The ISR total change included 7259 patients and showed a highly significant trend in an F statistic versus constant model with F = 169, p = 3.13 e − 38.

Module detection followed by a meta-analysis on chronological age identified fifteen consistently coexpressed PPI modules associated with chronological age, including a highly significant module ( P = 3.5 × 10 −38 ) enriched for ‘ T-cell activation ’ marking age-associated shifts in lymphocyte blood cell counts ( R 2 = 0.603; P = 1.9 × 10 −10 ).

The most highly significant variant at 5q33.1 (rs17728338) shows opposing effects on AD and psoriasis (MNM p = 3.96 × 10 −38 ; Table S5 ) and lies 2 kb upstream of ANXA6 (MIM 114070 ) and 8 kb downstream of TNIP1 (MIM 607714 ).

In addition, a highly significant number of these genes have a SMARCB1 ChIP-seq peak ( p -value = 5.43e −38 , Fig. 5b ), confirming that genes regulated by SWINGN share their regulation with SWI/SNF.

A highly significant S-PrediXcan signal ( p = 6.10e–38) was also obtained for this WDR19 intron cluster in testis, however the evidence for colocalization with the GWAS peak was low (PP.H4.abf = 0.39).

The QPHSg.wsu-2D locus was highly significant in this GWAS (7.64 < –log 10 ( p ) < 37.13), and had strong effects (0.02 to 0.72).

We observed a highly significant correlation ( R 2 = 0.5086, p = 8.5e−38; data not shown).

Another study [ 8 ] reported that infection rates are higher in metropolitan cities with large population density in India as they found a fair and highly significant correlation ( r = 0.49, p-value ~ 10 −37 ) at the 5% level of significance.

58 Variations in the gene encoding glutamate decarboxylase-like protein 1 (GADL1) were found to be associated with response to lithium with an extraordinarily highly significant P value (P=10 37 ).

In contrast, subtle but highly significant differences were evident between the velocity profiles of correct and incorrect saccades at long rPTs (mean peak velocity, correct versus incorrect: monkey R, p = 10 −37 ; monkey T, p = 10 −50 ; monkey G, p = 10 −27 ; Wilcoxon rank-sum test; Fig. 2c ).

The Jaccard similarity coefficients and the highly significant p -values (hypergeometric test p < 1 × 10 −37 in all cases) of the overlap of the top upregulated genes in DN and the GNs indicated that upregulated genes were common not only among FSGS, MN and IgAN, but also among DN and the three GNs ( Figure 1B ).

Genes overexpressed in old but not young Nrg1 tg-type I mice (Supplementary Table 3 ) included many with immune and inflammatory functions, and IPA generated two highly significant networks ( p = 10 −37 and p = 10 −34 ; one is shown in Fig. 1e , the other in Supplementary Fig. 4 ).

The difference was highly significant (Mann–Whitney p = 1.0E–37); (2) location of matching regions: In non-seed-binding miRNAs/isomiRs, we observed that over half of the matching regions began between positions 6 and 8.