“highly significant”

Still, for the remaining animals, the differences in the number of detected SNPs were highly significant ( P < 10 −20 ).

While the prediction of these algorithms was far from being perfect for each individual RNAi trigger, we found a highly significant correlation (Pearson = 90.6%, p < 10 −20 ) between this algorithm’s scores and our average screen score.

GO overrepresentation within the 531 gene cluster 7 (macronuclear G1/S, late micronuclear S) showed a highly significant enrichment for processes linked with S phase, including DNA replication ( P = 1.00E-20), DNA repair ( P = 1.03E-18), regulation of the G1/S transition ( P = 0.04), and histone modifiers ( P = 3.36E-3) ( Figure 6B ; Supplemental Datafile 2).

Most notably, we observe a highly significant dysregulation of WNT11 →FZD1, WNT11 →FZD3 and WNT11 →FZD7 in stage II ( P -value < 10 − 20 ), as well as of WNT11 →FZD7 in stages I and II.

Statistical testing further confirmed a highly significant increase in DSC and decrease in AVG HD for both improvements (competition and information aggregation) compared to QuickNAT (Wilcoxon signed-rank test, p < 10 −20 after Bonferroni correction for multiple testing).

This effect is strongest for the pairwise deviation between means (61% reduction), but also highly significant for the other measures ( P < 10 −20 in all cases).

Nevertheless, the above fraction of 77% validated genes is highly significant with a Binomial tail p-value < 10 -20 .

The ciliary modules were found to share on average more than 50% of genes with each other, this overlap statistically highly significant (P<10 −20 for the least significant pair of the datasets; see Table S4 for details on the cross-dataset overlap of the modules).

The overlaps between the studies were highly significant in most cell types ( P < 10 −20 , hypergeometric test) with the exception of the case of chimpanzee OPCs, because no genes were shared in this case ( SI Appendix , Fig.

[ 5 ], where they demonstrated a highly significant enrichment for genic regions within the group of loci identified as potential targets of positive selection (p < 1E-20).

These overlaps are highly significant (Fisher’s exact test, p<10 −20 ).

We found a highly significant enrichment, treated as a sample of either ordered or disordered regions (P<1e-20).

Fourth, there is a highly significant enrichment for extreme iHS values in genic regions ( p < 10 −20 in all populations; Table S1 ).

Differential expression was also highly significant ( P < 10 −20 ) for previously described TB markers, such as IP-10, LBP, FCG3B, and TSP4, and for many novel proteins not previously associated with TB.

As further confirmation of the quality of the model, analysis of variance of cross-validated residuals (CV-ANOVA) for the PLS-DA model was highly significant (p<1x10 -20 ).

We observed highly significant ( p < 1e−20) enrichment for the GO biological process (BP) term “translation”, GO molecular function (MF) term “structural constituent of ribosome”, and GO cellular compartment (CC) term “ribosome” among GO terms for differentially downregulated genes in external cortical tissues after 3 months of storage.

The highly significant enrichment patterns ( p <1e −20 ) highlight three fundamental mechanisms underlying GR’s superior thermotolerance.

The three large duplications in wMelPop, wMel2_a and wMel2_b were highly significant (t tests: p <10 −20 ).

It exhibited highly significant associations with multiple musculoskeletal traits, most notably with appendicular lean mass ( p = 1.0 × 10 −20 ), trunk fat-free mass ( p = 1.8 × 10 −8 ), and standing height ( p = 2.0 × 10 −9 ).

Each of the three possible pairwise regressions were highly significant with p<10 −20 .

Two highly significant loci mapped to chromosome 17 and chromosome 4 After the Hardy-Weinberg equilibrium test (Fisher’s exact test, P -value > 10 −20 ), 15,092,493 biallelic SNPs on all 29 autosomes remained for the GWAS.

A highly significant association peak (–log 10 ( P ) = 19.89) was identified on chromosome 1, exceeding the significance threshold (interval: 36,313,286–36,586,879 bp, spanning approximately 273.6 kb).

The intraclass correlation coefficient (ICC) for the accuracy rate was 0.982, indicating near-perfect agreement between raters, with a highly significant F test ( P = 1.36 × 10 −20 ).

The association between PRS and phenotypes of the same trait were highly significant (PRS 25-OH-D p = 1.4e − 20, PRS n3-PUFA p = 9.3e − 6, PRS MDD p = 1.4e − 4).

The relationship between the time point and membership of the clusters was highly significant (chi 2 P = 1.4 −20 ).