“highly significant”

Differential expression was also highly significant ( P < 10 −20 ) for previously described TB markers, such as IP-10, LBP, FCG3B, and TSP4, and for many novel proteins not previously associated with TB.

Two highly significant loci mapped to chromosome 17 and chromosome 4 After the Hardy-Weinberg equilibrium test (Fisher’s exact test, P -value > 10 −20 ), 15,092,493 biallelic SNPs on all 29 autosomes remained for the GWAS.

There is a substantial (average coefficient -0.6) highly significant (p<10 −20 ) shift of the distribution towards negative values for contrast-dependence (bottom histogram), together with a mild (∼0.16) less significant (p<0.01) shift towards positive values for SNR-dependence (top histogram).

Moreover, the overlap between the hyper- and hypo-methylated ESSEs in the Jurkat cells and DLBCL samples was highly significant ( p-value < 1E-20) (top panels, Fig 8B ).

As further confirmation of the quality of the model, analysis of variance of cross-validated residuals (CV-ANOVA) for the PLS-DA model was highly significant (p<1x10 -20 ).

We found a highly significant enrichment, treated as a sample of either ordered or disordered regions (P<1e-20).

The overlaps between the studies were highly significant in most cell types ( P < 10 −20 , hypergeometric test) with the exception of the case of chimpanzee OPCs, because no genes were shared in this case ( SI Appendix , Fig.

The three large duplications in wMelPop, wMel2_a and wMel2_b were highly significant (t tests: p <10 −20 ).

Two-by-two χ 2 tests comparing each mutant to ndt80 Δ at the same threshold confirmed that all contrasts were highly significant (χ 2 = 86.7–197.2, df = 1, p < 10 −20 ; full statistics in Table S2 ).

These overlaps are highly significant (Fisher’s exact test, p<10 −20 ).

Among them, the pink, purple, yellow, and turquoise modules were highly correlated with the 2-cell to morula stages ( Supplementary Figures S3A,B ), and the correlation was highly significant based on the p value ( p < 10 –20 ).

The ciliary modules were found to share on average more than 50% of genes with each other, this overlap statistically highly significant (P<10 −20 for the least significant pair of the datasets; see Table S4 for details on the cross-dataset overlap of the modules).

While the prediction of these algorithms was far from being perfect for each individual RNAi trigger, we found a highly significant correlation (Pearson = 90.6%, p < 10 −20 ) between this algorithm’s scores and our average screen score.

[ 5 ], where they demonstrated a highly significant enrichment for genic regions within the group of loci identified as potential targets of positive selection (p < 1E-20).

This effect is strongest for the pairwise deviation between means (61% reduction), but also highly significant for the other measures ( P < 10 −20 in all cases).

Nevertheless, the above fraction of 77% validated genes is highly significant with a Binomial tail p-value < 10 -20 .

Fourth, there is a highly significant enrichment for extreme iHS values in genic regions ( p < 10 −20 in all populations; Table S1 ).

The overlap of Arc-dVenus -enriched genes with activity-regulated and visual stimulus-induced genes is highly significant (each p < 10 −20 , hypergeometric test) ( Fig. 3C,D ).

Still, for the remaining animals, the differences in the number of detected SNPs were highly significant ( P < 10 −20 ).

The highly significant enrichment patterns ( p <1e −20 ) highlight three fundamental mechanisms underlying GR’s superior thermotolerance.

Each of the three possible pairwise regressions were highly significant with p<10 −20 .

A highly significant association peak (–log 10 ( P ) = 19.89) was identified on chromosome 1, exceeding the significance threshold (interval: 36,313,286–36,586,879 bp, spanning approximately 273.6 kb).

The intraclass correlation coefficient (ICC) for the accuracy rate was 0.982, indicating near-perfect agreement between raters, with a highly significant F test ( P = 1.36 × 10 −20 ).

The relationship between the time point and membership of the clusters was highly significant (chi 2 P = 1.4 −20 ).

The association between PRS and phenotypes of the same trait were highly significant (PRS 25-OH-D p = 1.4e − 20, PRS n3-PUFA p = 9.3e − 6, PRS MDD p = 1.4e − 4).