“highly significant”

Results With all possible fMRI contrast parameters, the three-factor models were highly significant ( p < 1.0 x 10 -21 ).

Highly significant associations for a nonsynonymous SNP (rs12075; G42D ( NP_002027.2 ) ( p = 1.3E-21) and an intronic SNP ( p = 3.6E-13) in DARC on chromosome 1 were identified for MCP-1.

Rs17822931-G showed highly significant association in the combined samples of 174 cases and 201 controls (P = 1.42E-21, OR = 83.94, 95% CI = 83.03–84.85).

The difference between CTA and all genes was highly significant with Mann–Whitney U test p -value = 1.47E-21, and likewise for CTX versus all genes with p -value = 1.16E-23.

MR analysis in the same study provided further highly significant evidence of a causal relationship between mLOY and AF (HR: 1.15, 95% CI: 1.13–1.18, p = 1.52 × 10 −21 ).

2 B) but with a highly significant effect ( P = 1.57*10 -21 after PLS-DA cross-validation ANOVA). 3.3.

( 2017 ) overlapped with our set of 2,379, which is highly significant (hypergeometric test p = 16.8 × 10 –22 ) and suggestive of commonalities among transcriptomic stress responses, whatever the underlying trigger.

Two highly significant DMRs (DMR1 p = 2.72E-21; DMR2 p = 1.84E-08) were discovered within the primary and alternative promotors and leading exons of the MAP2K3 gene that encodes the MAP kinase kinase, MKK3 (Fig. 4 b).

This overrepresentation of prophage DNA is highly significant (binomial test, P = 3 × 10 −21 ).

The mean ΔPPD ( ± SE) for the bTB+ animal group was 1170.35 ± 84.48 compared to −360.46 ± 55.17 for the bTB− group and this group difference was highly significant (two-tailed Wilcoxon rank-sum test; P < 3.258 × 10 −21 ) (Supplementary Fig.

In fact, highly significant abundance of cis configurations of PFA-nsSNPs was obtained, with a global cis/trans ratio of 59.6:40.4 ( P < 3.53 × 10 −21 ) (Table 1 ).

Thus, more than 50% of TCF target genes were differentially expressed in the 2 subpopulations, reflecting highly significant enrichment for TCF1 target genes among differentially expressed genes ( P = 3.56e-21).

In monocytes, highly significant enrichment was observed for regulation of inflammatory response (GO:0050727, p = 3.95 × 10 −21 ), positive regulation of innate immune response (GO:0045089, p = 2.69 × 10 −18 ), the innate immune response-activating signaling pathway (GO:0002758, p = 2.69 × 10 −16 ), canonical NF-kappaB signal transduction (GO:0007249, p = 3.00 × 10 −9 ), and the tumor necrosis factor-mediated signaling pathway (GO:0033209, p = 0.001).

We observed a highly significant correlation between the signature count score and ME in the Test dataset (OR = 1.23 per standard deviation increase, p = 4 × 10 − 21 ) when including sex and the top 10 genetic principal components as confounders in the logistic regression.

This SNP was also highly significant in our analysis ( p = 5.4 × 10 −21 , beta = 0.27 years, effective-allele = G).

Finally, Fbp1 had a highly significant cis eQTL (rs13481847; P =6.1×10 −21 ) in the cochlea that maps ∼100 kb upstream of our peak GWAS SNP on chromosome 13 for ABR threshold after a 24-kHz tone burst.

Results demonstrated that all the three main effects were highly significant: semantic context, F (1,65) = 189.567, p = 6.12e−21, partial η 2 = 0.745; F 0 contours, F (1,65) = 277.133, p = 3.948e−25, partial η 2 = 0.81; group, F (1,65) = 22.554, p = 1.167e−5, partial η 2 = 0.258.

This is a highly significant overlap ( p = 6.14 × 10 –21 by hypergeometric probability).

Urate is relatively low down the list (27 th position), but nonetheless enough data is available to yield a highly significant (top hit p-value = 7.29 x 10 -21 ) GWAS result ( Figure 1 ).

Discussion The BCO2 mutation ( c.196C>T ) identified in the present study showed a highly significant (P = 7. 44 × 10 -21 ) association with yellow adipose tissue in 428 genotyped sheep.

The overlaps between the studies were highly significant in most cell types ( P < 10 −20 , hypergeometric test) with the exception of the case of chimpanzee OPCs, because no genes were shared in this case ( SI Appendix , Fig.

Among them, the pink, purple, yellow, and turquoise modules were highly correlated with the 2-cell to morula stages ( Supplementary Figures S3A,B ), and the correlation was highly significant based on the p value ( p < 10 –20 ).

Fourth, there is a highly significant enrichment for extreme iHS values in genic regions ( p < 10 −20 in all populations; Table S1 ).

The overlap of Arc-dVenus -enriched genes with activity-regulated and visual stimulus-induced genes is highly significant (each p < 10 −20 , hypergeometric test) ( Fig. 3C,D ).

There is a substantial (average coefficient -0.6) highly significant (p<10 −20 ) shift of the distribution towards negative values for contrast-dependence (bottom histogram), together with a mild (∼0.16) less significant (p<0.01) shift towards positive values for SNR-dependence (top histogram).