42 Though these mutations don't cause cancer but instead they cause “Clonal hematpoiesis of indeterminate significance”.
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“indeterminate significance”
Sighted at
p=0.08
In the literature
EUS showed a homogeneous hypoechoic lesion in the cephalicregion of uncinate pancreas process and fine needle puncture showed cells with atypia of indeterminate significance.
At the conclusion of the dosing phase, microscopic findings of indeterminate significance were observed in the livers of some female animals.
The comment in the Discussion, re DNA methylation 'epi-signatures' should also take into account that these are being used as 'biomarkers' to help improve diagnosis of variants of indeterminate significance in monogenic traits.
Realizing the ever-increasing demand for quality healthcare, contemporary AI has been envisioned to make great strides in clinical data management and perception, with the capability to detect indeterminate significance, predict prognostication, and correlate available data into a meaningful clinical endpoint.
The "indeterminate" result represents a "gray" diagnostic area, which occurs in 5–20% of cytological reports with the presence of cellular atypia of indeterminate significance (TIR3 category) [ 11 ].
The results of cytology testing reported that 48 (8.5%) women had cervical abnormalities, which included 16 (2.8%) classified as ASCUS (Atypical Squamous Cells of Unknown Significance), 6 (1.1%) classified as ASCH (Atypical Squamous Cells of Indeterminate Significance), 16 (2.8%) classified as LGSIL (Low-Grade Squamous Intraepithelial Lesion), 4 (0.7%) classified as HGSIL (High-grade squamous intraepithelial lesion), and 6 (1.1%) classified CIN II + CIN III (Cervical Intraepithelial Neoplasia) (Table 1 ).
Cytological results of non-diagnostic lesions and lesions of indeterminate significance (atypia of undetermined significance, and suspicions of follicular neoplasm and malignancy) without surgical confirmation were excluded from the study.
The Afirma Gene Expression Classifier assists in decision making regarding surgical recommendations for aspirates with cytology of indeterminate significance or follicular lesions [ 12 , 56 ].
Of the three false-positive CT results two described small pulmonary nodules of indeterminate significance, which were unchanged on follow-up CT, and one described a liver lesion that was too small to characterise, but was shown to be a cyst on subsequent US.
Chest CT performed at initial presentation showed only two small pulmonary nodules of indeterminate significance.
Diagnostic imaging included a CT head without contrast that demonstrated rounded hyperattenuating focus in the frontal horn of the bilateral lateral ventricle measuring approximately 9 × 7 mm (right) and 5 × 4 cm (left) transaxially, of indeterminate significance ( Fig. 1 ).
Nasal swab culture during FESS grew mixed faecal flora of indeterminate significance.