“indeterminate significance”

After a while it becomes necessary for him to take refuge in the no man’s land of “dysplasia” and other “entities of unknown or indeterminate significance” and, compiling data for “predicting outcome,” he becomes something like a haruspex, this diviner of antiquity whose function was to predict, for the benefit of the Emperor (the clinician), the issue of a battle by reading in the viscerae of a sacrificed animal (the patient) ( Figure 1 ).

About 20% of the cytology results from thyroid FNA come back as an indeterminate result, which includes atypia or follicular lesion of indeterminate significance (Bethesda III) (AUS/FLUS) and follicular neoplasm/suspicious for follicular or oncocytic (formerly Hurthle) neoplasm (Bethesda IV) [ 2 ].

[ 41 ] However, while the utility of scripted patient communication tools is of indeterminate significance on the patient experience, there is ample evidence supporting the educational utility of the learning framework of our intervention.

It should have a high negative predictive value for cytologic samples of indeterminate significance.

A chest CT scan revealed multiple small nodules of indeterminate significance.

His medical history included hepatocellular carcinoma (HCC), type 2 diabetes, and monoclonal gammopathy of indeterminate significance.

The nodule was of indeterminate significance and etiology.

For the proportion of the posterior distribution in the ROPE, the following are considered: <1%: Significant; <2.5%: Likely significant; ≤97.5% and ≥2.5%: Indeterminate significance; >97.5%: Likely insignificant; >99%: Insignificant ( 21 ).

A pathogenic variant in the SDHD gene, namely c.3G>C (Initiator codon) was identified, while his previous MEN2A mutation of indeterminate significance was deemed not pathogenic.

Among probands rated as variants of indeterminate significance, the judgment of pathogenicity was often affected by lack of evidence such as de novo data (with or without paternity and maternity confirmed) —PS2/PM6, and functional data —PS3/PM1/PP2.

Nonspecific findings (defined as radiologic abnormalities of indeterminate significance requiring follow up as reported by the radiologist) were detected in 89 SIs (68 CT scans, 19 bone scans and two abdominal ultrasounds), which triggered a total of 138 follow-up radiological scans in 71 (42%) of the 168 patients that had initial Sis, including: CT scan (n = 75), ultrasound abdomen (n = 29), MRI liver (n = 14), bone scan (n = 4), chest X-ray (n = 5), bone X-ray (n = 5), MRI spine (n = 4) and PET scan (n = 2).

In the study by Deandrea et al., the smears diagnosed as follicular lesions of indeterminate significance and follicular neoplasm had a RoM of 4.95% and 25% each.

Somatic Mutations in Hematopoietic Stem Cells Age-related somatic mutations in hematopoietic stem cells may result in clonal hemopoiesis of indeterminate significance (CHIP), which increases the risk of hematologic malignancies, CVD and overall mortality [ 98 , 99 ].

33 (9.19%) samples were classified as non-diagnostic (Bethesda I), 149 (41.50%) as benign (Bethesda II), 47 (13.10%) as atypia of indeterminate significance/follicular lesion of indeterminate significance (AUS/FLUS, Bethesda III), 7 (1.95%) as follicular neoplasm/suspicious for follicular neoplasm (FN/SFN, Bethesda IV), 17 (4.74%) as suspicious for malignancy (SUSP, Bethesda V), and 123 (29.53%) as malignant (Bethesda VI).

The term clonal hematopoiesis of indeterminate significance (CHIP) was introduced to describe individuals with a hematologic malignancy-associated somatic mutation in peripheral blood or bone marrow cells but without any other diagnostic criteria for a hematologic malignancy. 107 CHIP must be distinguished from myelodysplastic syndromes (MDS) by the absence

These cytological diagnoses are determined, as follows: 1) Bethesda I, nondiagnostic or unsatisfactory, 2) Bethesda II, benign, 3) Bethesda III, atypical of indeterminate significance or follicular lesion of indeterminate significance, 4) Bethesda IV, follicular neoplasm or suspicious for a follicular neoplasm, 5) Bethesda V, suspicious for malignancy, and 6) Bethesda VI, malignant.

Alteration in Malignancy Rate with the Introduction of Non-Invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) Since significant portions of noninvasive FVPTCs are categorized as atypia of indeterminate significance (AUS), suspicious for follicular neoplasm (SFN) and suspicious for malignancy (SUS), the greatest impact of this new nomenclature was expected in these categories [ 6 , 16 , 17 ].

The fact that these unrequested findings can be detected without additional radiation exposure is pitted against the indeterminate significance of many unrequested findings and the risk and cost of provoking unnecessary follow-up.

This renders the fine-needle aspirates (FNA) of thyroid follicular nodules useless for diagnostic purposes and biopsies not allowing for determination of the lesions malignant potential are determined as of indeterminate significance [ 5 ].

We analyzed 2 groups of variants found in 8 genes with definitive evidence for HCM ( 3 ): sarcomeric variants P/LP specifically for HCM (SARC-HCM-P/LP) and rare sarcomeric variants of indeterminate significance (SARC-IND) with the potential to cause HCM, dilated cardiomyopathy (DCM), or have little impact on cardiomyopathy risk.

MRI offers excellent tissue differentiation and serves as a valuable tool for characterizing lesions that may contain fat observed upon CT or ultrasound with indeterminate significance.

(0 and 1 were collapsed since 1 represents signal hyperintensity on T2-weighted images of indeterminate significance.) Meniscal damage was scored as: 0: normal, 1: intra-substance signal, 2: tear, 3: maceration/resection.

Findings include bilateral calcifications of indeterminate significance, with the breast showing a mixture of fatty and dense fibrous tissues.

Another potential challenge of NGS is the detection of novel variants and mutations of indeterminate significance.

reported that 47.3% of endocrinologists opted to repeat FNA in cases of AUS/FLUS (follicular lesion of indeterminate significance), while only 14.1% selected molecular testing due to its limited availability [ 20 ].