“likely to be significant”

Based on the WPI network, we identified genes and their interactions that are likely to be significant and involved in the cell cycle.

Intra- and inter-tumour heterogeneity in mutation burden are also likely to be significant determinants of treatment response, and are not routinely considered in current binary ‘wild-type/mutant’ tumour classifications.

The impact of PGF beyond the first month after transplantation is less clear, but also likely to be significant.

As these data come from a polyclonal pool of drug-resistant MEFs, there is likely to be significant variation in the level of Usp44 over-expression.

In one case, based on simulations of IRS/ITN combined interventions, Yakob et al [ 16 ] recently reported that even though there is likely to be significant reduction of transmission by using 80% coverage with pyrethroid treated ITNs and DDT together at household level, this combination still resulted in higher transmission potential (basic reproductive number, R o = 11.1 down from an control baseline of 39.5), than 80% coverage with just the ITNs alone without the DDT (R o = 0.1).

When ART coverage is low this will not have a large effect but as ART coverage is increased this effect on transmission is likely to be significant.

This is likely to be significant for development of atherosclerosis, taken together with the finding that removal of CMR from the blood is delayed in several common conditions such as obesity and type 2 diabetes [ 34 ].

With more columns to be counted, larger genes are more likely to be significant in LRTs.

However, it is increasingly apparent that regional variation in temperature and humidity are likely to be significant in understanding the impacts on insect populations (Easterling et al., 2000 ; Tebaldi and Sansó, 2009 ; Benoit and Denlinger, 2010 ).

This is likely to be significant for development of atherosclerosis, particularly when the removal of CMR from the blood is delayed as occurs in relatively common conditions such as obesity and type 2 diabetes [28] .

For many of the pairs of countries the numbers of co-publications were too small to make determination of time trends reliable, but the table below shows where the numbers are likely to be significant.

Although there are few data available on proteomic analysis of human neutrophils [ 10 ] this is an area of interest growing that is likely to be significant in future investigations.

The order of PTEN and CDK4 determined for samples belonging to the proneural subtype, however, passed the threshold of 58% flux through the network and also had a p-value for correlation of 0.02, and was therefore more likely to be significant.

Direct physical impacts at active sites on the spatially restricted hydrothermal vent fauna are likely to be significant initially, with the removal of habitat and a largely endemic fauna [75] . 1.6 Seamounts are very slow to recover from impacts Recovery of vulnerable species, and the assemblages which they form, from human impacts is predicted to be very slow in the deep sea [76] .

However, it is clear that multiply hydrogen bonded triples, which consist of at least two hydrogen bonding interactions per base, will be especially stable and the structural conservation of such triples is therefore likely to be significant.

Although such a subset of children is likely to constitute a limited proportion of the general ASD population, given the high prevalence of ASD, the absolute number of individuals who could be protected is likely to be significant.

Consequently, sequence identity and high sequence similarity were likely to be significant sources of redundancy.

Other emerging issues reported in the literature that are likely to be significant barriers for teams of allied health, though not evident in the results of this study, are managing the role of consumers in research and the challenges of mixed methods, multidisciplinary approaches, and multinational research studies. 3 , 41 The results of this study identify differences in the motivators, enablers, and barriers that operate for the individuals and teams within an organization.

Cummings et al reported that up to 30% of falls are not recalled even in a 1-year period; 26 thus, there is likely to be significant recall bias in this study design.

On the other hand, if random points are chosen at a scale that includes heterogeneous types of habitat, some of the more general variables are more likely to be significant [e.g. altitude] , [ slope or vegetation cover] ; [ 13,57,65] .

The results suggested that the variants from the same CDKN2B-AS1 locus were likely to be significant for NPG patients.

Discussion The key issues in deciding whether to introduce a new screening programme include whether: (1) screening represents a cost-effective intervention (i.e., the health gains are likely to be significant compared with the costs involved); (2) uptake is likely to be sufficiently high for screening to be effective; and (3) implementation is feasible (i.e., sufficient health service resources are available to diagnose, treat and follow-up those found to have adenomas and cancer).

However, given that 5–15% of the adult population is affected, the direct and indirect economic consequences of the disease are likely to be significant.

To this aim, we have tested whether there is a significant association between karyotype and time to death under desiccation stress to assess resistance to dehydration, a trait that is likely to be significant for the survival of populations living in the more xeric portions of this species’ extensive geographical range.

This level of BIM up-regulation is likely to be significant because BIM up-regulation induces apoptosis unless its activity is concomitantly suppressed by overexpression of antiapoptotic BCL-2 family members ( O’Connor et al., 1998 ).