Barely Significant
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may be significant

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In the literature

1 Although the incidence of IBD in patients treated with ISO is low, the consequences for an individual developing IBD may be significant. 21 Doctors can avoid providing ISO to IBD susceptible patients as much as possible by inquiring about family or personal medical history, in order to avoid serious consequences.
The influence of the joint phosphorous contribution of piscivorous and herbivorous water birds may be significant (up to 6.6% of P at the outflow) on the often phosphorous-limited wetland nutrient loads, while the nitrogen contribution dominated by herbivorous geese is limited (up to 0.7% of N at the outflow) in the case of Dumbrăvița.
Given that there may be significant variations in illness presentations, treatment outcomes and service need between patients with typical age of onset (i.e., late adolescence or early adulthood) and those having their psychosis manifested at later years ( 22 , 23 ), together with recent extension of some early intervention services to cover a wider adult age range (e.g., in United Kingdom and Hong Kong) ( 23 , 24 ), more research is required to clarify self-stigma and its associated factors in early psychosis patients at higher-age groups.