Barely Significant
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may be significant

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In the literature

The authors postulated that, as Malassezia is known to produce antigenic proteins that can trigger Ig E-mediated immunogenic responses in atopic skin diseases [ 91 , 92 ], this alteration in the microbiome may be significant in the pathophysiology of SAC/PAC.
Impact of Exposomes on Ocular Surface Diseases.
Int J Mol Sci · 2023 · PMC10379833
Using resistive methods (such as coaxial shunt current sensor), the primary circuits are directly connected to the sensing circuits, which may not be a major concern in low-voltage electronics; however, it is of greater concern in power electronics, where the common mode voltage difference may be significant between the various circuit components, highlighting the absence of electrical isolation.
This latter finding fits well with the concept of chronotype, as well as with the definition of morningness–eveningness as preferred time schedules or the degree to which respondents are active and alert at certain times of day 48 , 49 .The finding that sleepiness is lowest during the midday, but the timing of its nadir is affected by an individual’s chronotype, may be significant in the prediction and prevention of sleepiness-related accidents.
Myocarditis during active covid infection is frequently sub-clinical and underdiagnosed, but its prevalence may be significant. 5 The long-term prognosis of myocarditis in this setting is still unknown, and further study is needed to determine whether COVID-19 myocarditis has similar outcomes compared with myocarditis from other causes.