Barely Significant
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may be significant

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In the literature

Furthermore, when considering direct transmission of viral pathogens from mother to offspring, the pathological consequences may be significant despite preexisting maternal seroimmunity, as demonstrated by the relevant morbidity and mortality observed after transplacental infections with viruses other than RSV, such as cytomegalovirus (CMV) and pestivirus [32] , [33] .
This has an additional benefit to be directly extensible to the alignment of pre-computed alignments representing replicates of different cell states (where signal-to-nothing matches may be significant), and allows one to tackle the problem of an arbitrary number of cell states with the same conceptual framework and finite computational resources.
It is likely that the 4 fenestrations in Nav1.2 and Nav1.4 are differentially sized as a consequence of such amino acid differences between the 4 repeats, but since there may be significant structural differences between eukaryotic and bacterial VGSCs, it is difficult to tell if residues at other positions in the sequence contribute to fenestration bottlenecks in eukaryotic VGSCs or if structural differences contribute to a widening or restriction of the fenestrations in other ways.
Osmoregulation-related genes such as delta-1-pyrroline-5-carboxylate synthase ( P5CS ), Amino acid permease ( AAP ), Amino acid permease 2 ( AAP2 ) and Trehalose-phosphate synthase ( TPS ), as well as the antioxidant enzyme L-ascorbate peroxidase 6 ( APX6 ), may be significant genes involved in drought tolerance in G. sinensis .
The mechanism of this rebalancing is not known, but it may be significant that once wild type cells have been lost, the mutant epithelium becomes crowded, with a 30% increase in the density of basal cells and buckling of the epithelium, consistent with increased mechanical stress 50,63 ( Fig. 3B and C ). 50,63 These changes are reminiscent of epidermis exposed to ultravi
Cell competition: winning out by losing notch.
Cell Cycle · 2015 · PMC4352972