“might be significant”

Discussion Transudation from pathological tumor vessels, secretion by tumor cells, and obstruction of the CSF flow by an intramedullary tumor might be significant factors for the development of syringomyelia.

In this respect, differences in the reported preferred angle of division, vertical for embryonic radial glia and horizontal for adult NSCs in the SGZ (Kempermann et al., 2004 ; Bonaguidi et al., 2011 ) might be significant.

Prognosis quoad vitam is good, although morbidity might be significant, especially in children and adolescents.

This might be significant in prognosis and the need of specific treatment of cases.

However, the results must be interpreted carefully and not be considered as an indication for suggesting energy independence (no external energy input needed) of treatment concept, because i) the energy input in the commercial reactor system only measured the electric energy used for heating the vessel; energy input from other units such as process parameter monitoring and controlling devices might be significant, and ii) the HHV of HC was obtained by bomb calorimetry carried out under surplus provision of oxygen.

Even though SMD was used to understand DMDD in the present review, the relatively small difference between DMDD and SMD criteria might be significant and becomes evident when examining youths on a group level.

Since the overall spherical equivalent refraction was less than 1 diopter, the amount of refraction changed might be significant.

Second, there might be significant predictors of outcomes that are not available in our data set, such as insurance status, dependency status, income levels, and details of spinal pathology.

This suggests that SGWs might be significant to the Southern Ocean mixed layer, which is a region where zonal symmetry is a reasonable first‐order simplification (Smith et al., 2006 ).

Alternatively, a pathway that overrides the p53-p21 inhibitory loop without affecting the pro-apoptotic function of p53 might be significant in driving apoptosis following DNA damage.

Finally, quantum tunneling might be significant, especially in the case of narrow energy barriers and/or particles of small mass such as protons.

Research have revealed that there might be significant regional variation in the biochemical characteristics of different plants.

On the other hand, the contribution of other components of MSCs secretome (EVs or cytokines and growth factors beyond those analyzed in this study) might be significant enough to mitigate the difference between CM from 2D and 3D cultures when assessing their effect on macrophage polarization.

We conducted network meta-regressions, which showed that there might be significant interactions between total blood loss and age, while there were no significant interactions between total blood loss and BMI or the use of tourniquet or whether bilateral or unilateral TKA.

Given that some statins had clear advantages over others in decreasing the morbidity and mortality of infection when administered pre-infection ( 31 ), studying the effects of different satins might be significant.

Therefore, it is important to explore what might be significant predictors of improving HSU behavior.

First is the route of administration: GLP-1R agonists require subcutaneous administration, whereas DPP-4 inhibitors are delivered as oral tablets, and this difference might be significant in terms of convenience of use and adherence to therapy.

It would seem difficult to orchestrate a sufficient multiplicity of correlative attractor effects, though Fgf8 signal present at the commissural septum might be significant, due to evidence that it may attract glutamatergic neurons (Pombero et al. 2011 ).

Conclusion Grade 4 invasion and perineural invasion might be significant minor risk factors in OSCC patients.

As more patients could be recruited, the expression level of IL-17 between early- and advanced-disease might be significant.

Moreover, women might face problems with health service access (70.2%), might have poor health-seeking behavior, high transportation costs, and inaccessibility of health facilities might be significant reasons for low coverage of childhood vaccination in Ethiopia [ 77 ]. 70% and 30% of total observations were set for model training, and model evaluation, respectively.

There might be significant discordance at the level of alignment and even the specific lists of DE genes, but if they result in the same pathway enrichment results then it is likely the same conclusions will be drawn from each analysis; and indeed, this is what was observed in this study.

(2) Given the highly abundant expression of METTL3 in various cancer cell lines, we speculate that there might be significant excess of METTL3 unbound to METTL14, which explains its dose-dependent regulation of METTL14 stability.

For instance, in regional and remote areas, there may only be one site and travel distances to the site might be significant, which presented a barrier to clients if they did not have transport to the service.

The difference might be significant in the context of deletions as this might mean that our samples had more deletions than the BCG Danish strain used for vaccination in South Africa.