Barely Significant
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of borderline significance

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In the literature

However, by the year of diagnosis, there was a 57%–70% increase in not starting TB treatment among those diagnosed with TB in 2021/22 as compared with 2020/19, and a significant drop in TB treatment coverage for males and of borderline significance for females diagnosed in 2021/22 as compared with 2019.
A trial of predischarge intravenous ferric carboxymaltose to patients who had been hospitalised with acute heart failure (AFFIRM-AHF)) suggested that treatment to 6 months might reduce the risk of recurrent hospitalisations for heart failure but not cardiovascular mortality when assessed at 52 weeks, although the effect on its primary endpoint, a composite of recurrent hospitalisations for heart failure and cardiovascular death, was of borderline significance. 6 A meta-analysis of seven randomised trials of patients with HFrEF and iron deficiency found that intravenous iron reduced the risk of hospitalisation for heart failure but was unable to demonstrate a reduction in cardiovascular mortality. 7 Major gaps in our knowledge remain, including the long-term benefits and safety of repeated administration of intravenous iron.
PMA combined with TCR activation (anti-CD3 + anti-CD28) also caused a highly significant increase in the phosphorylation of AKT (Thr308), mTOR (Ser2448) and STAT3 (Ser727) for both T cell subsets, but an additional increase in STAT3 (Tyr705) phosphorylation of borderline significance was observed only for CD3 + CD8 + cells after combined PMA+TCR stimulation ( Table 2 ).