Barely Significant
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of borderline significance

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In the literature

The mediation analysis revealed among women a significant indirect effect for exposure to physical effort for both SEP categories (middle SEP: NIE = 1.02, 95% CI: 1.01–1.03; low SEP: NIE = 1.03, 95% CI: 1.01–1.04) and repetitive work for the low SEP category (NIE = 1.03, 95% CI: 1.01–1.04), whereas the other results were only of borderline significance.
86 Taking all RCTs together, re-starting OAC was associated with reduced risk of ischemic stroke on the one hand, but increased risk (of borderline significance) for recurrent intracranial bleeding (ICB). 87 The threat of ICH recurrence is daunting, but many physicians will consider restarting anti-thrombotic therapy at least 30 days after the ICH. 88 The results of ongoing RCTs focusing on OAC vs no anticoagulation (without considering LAAC) in ICH patients with AF (such as ENRICH-AF, 89 PRESTIGE-AF, 90 A 3 ICH, 91 STATICH 92 and ASPIRE 93 ) are awaited.
COX-1 and COX-2 expression in epidermal and dermal inflammatory infiltration did not change significantly in either study group, but a significant decrease of COX-1 expression was observed when the groups were combined for analysis, and the decrease in COX-2 expression in the epidermis was of borderline significance.
14 Given the limitation of borderline significance due to the inadequate recruitment related to the COVID-19 pandemic, the research team decided to recruit more participants with clinical setting as a major comparison for this work, and hence the aim of this project.