The IMPrESS study showed that pwMS treated earlier in the course of the disease showed a trend towards lower total (€39,037 vs €42,996), indirect (€15,733 vs €18,934) and disease-modifying therapy (€19,364 vs €20,491) costs and a better health-related quality of life status (0.62 vs 0.56; p < 0.01) compared to those receiving late treatment [ 3 ].
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In the literature
Dietary antioxidant phytochemicals have demonstrated protective effects and the presence of these compounds in the traditional Mediterranean diet may be partly responsible for the low incidence of CMM in this area, despite high levels of solar radiation; other studies showed a trend towards a reduced risk of CMM with a greater intake of vegetables and fruit, fish, as well as vitamins and beverages such as coffee or tea [ 11 , 12 ].
Interestingly, for both male and female crabs, the proportion of Proteobacteria gradually decreased with age and the proportion of the Tenericutes showed a trend of decreasing first and then increasing.
CO 2 content was significantly higher in parafilm sealed Petri dishes after 7-day (4.2% higher), and the difference became even higher at 21-day (33.9%) while it showed a trend reversal after 14 days growth (16.2% lower).
The primary endpoint was the mean change in the lesion area from baseline to month 18 as measured by fundus autofluorescence ( 79 ).” The results showed a trend for a reduction in GA progression of 20% in the lampalizumab group, but there was no significant difference between the lampalizumab and sham groups ( 79 ).
As shown in Figure 6 F, the ROs of three groups showed a trend similar to the BRET versus time curve ( Figures 6 F and 6E).
(2) With decreasing water application, the cumulative percentage of root length, root surface area and root biomass in 4 rings from the center out to 12 cm of SW soil showed a trend of W50% > W30% > W100% in SW, however, the cumulative percentage of root biomass in 4 layers from the surface to a depth of 36 cm was not significantly different between different water treatments in DN.
daigremontiana always remained positive and showed a trend of decreasing first and then increasing during the different light/dark cycles conversion.
MiSeq data showed a trend for higher relative abundance of lactate-producing Enterococcus in both fermentations at 10-h RT compared to 5-h RT.
The GRIK2 gene showed a trend of downregulated expression levels across age ( Figure 1 ).
However, with the prolongation of the mineralization time, the conductivity showed a trend of increasing sharply first and then, more gradually, see Supporting Information, Figure S7 .
Interestingly, treatment did not produce any variation in plasma CoQ 10 content in the diabetic monkeys, while non-diabetic monkeys showed a trend towards a decline in plasma CoQ 10 , which was restored after the wash-out period ( Figure 3 A).
A recent analysis by the Robert Koch Institute showed a trend for increasing tetra-cycline resistant MRSA in recent years, where it has been observed among asylum seekers in central reception centers [ 20 ].
Control cancer cells displayed low E-cadherin levels, while both 5FU- and F6-treated cells showed a trend, albeit not significant, toward increased release ( Figure 8 a); β-catenin increases significantly only in 5FU+F6-treated cells, while showing a slight, albeit not significant decrease in the other treatment conditions ( Figure 8 b).
For CI treatments, except for the seed-setting rate, the other three yield components had a threshold value with the increase of N application, which showed a trend to first increase and then decrease, resulting in the same trend of yield change.
NPs targeted by anti-DC-SIGN antibody showed a trend of enhancing IL-8 and IL-12 production when compared to NPs targeted by ICAM3-Fc ( Figure 3 E).
While total average barriers showed a trend toward an association, this was not statistically significant.
5E ), showed a trend toward increased time spent exploring the open arms of an elevated plus maze ( Fig. 5F ), and diminished anxiety behavior as indicated by both reduced risk assessment and increased time spent in the bright arena of a Dark/Light maze ( Fig. 5G ).
Since analysis for the primary efficacy endpoint conducted in December 2015 showed a trend towards statistical difference between patients with SIBO and patients without SIBO, it was allowed for the study to enroll patients for another 6 months.
[ 13 ] commented that the lateral subgroup showed a trend toward greater improvements than the medial subgroup on nearly all knee scoring scales.
Mild nitration (10-fold excess of TNM) showed a trend towards a decrease, but this was not statistically significant. 4.
A Cox regression model indicated statistically significant worse 30-day survival in patients operated on with a surgical delay of 12 to 24 hours (HR: 8.30; 95% CI: 1.13-61.4) and ≥48 hours (HR: 11.75; 95% CI: 1.53-90.2) compared to <12 hours surgical delay, whereas surgical delay of 24 to 48 hours (HR: 7.21; 95% CI: 0.98-52.9) showed a trend toward worse survival.
Similarly, the more specific markers for late endosome-derived small EVs TSG101 and Syntenin showed a trend to increase in response to exercise.
Old HIV + VRs showed a trend of greater frequencies of Ag.pTfh compared to old HIV + VNRs, but it did not reach significance at post-vaccination ( Fig 1B ).
In the multivariate analysis, poor performance status showed a trend towards association with bleeding risk.