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“showed a trend”

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showed a trendp = 0.0641.3× alpha
Of note, the DMSO treatment group, which reflects the effect of shHic1 induction alone at D20 on Atoh1-Enh-Prom-NLuc activity, showed a trend consistent with FACS-based results, yet did not achieve statistical significance (p = 0.064), which likely reflects the limitations of the luciferase-based assay, which quantifies bulk expression changes in unsorted organoid populations.
showed a trendP = 0.0641.3× alpha
These findings were further validated across multiple independent cohorts: the Lauss 2017 CAR-T therapy cohort showed a trend toward improved PFS (P = 0.064), while the Cho 2020 (anti-PD-1/PD-L1, PFS, P = 0.021), IMvigor210 2018 (anti-PD-L1, OS, P = 0.0051), and Nathanson 2017 (anti-CTLA-4, OS, P = 0.04) cohorts consistently confirmed that high SLFN11 expression is associated with favorable prognosis in immunotherapy settings ( Figure 4B ).
showed a trendP = 0.0641.3× alpha
In addition, in regions of WMH, lower SUVR was associated with lower FA (β = + 0.24, P = 0.046; 95%CI bootstrap [+0.008, +0.47]) and showed a trend with higher MD (P = 0.064; 95%CI bootstrap [−0.44, +0.003]) across all subjects, but not with the fiber-specific metric FW-adjusted FA.