Comprehensive Profiling of Cancer-Associated Cells in the Blood of Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy to Predict Pathological Complete Response.

In a multivariate logistic regression model predicting pCR, CAML count was positively associated with the log-odds of pCR [OR = 1.49(1.01, 2.18); p = 0.041], while CTCs showed a negative trend [Odds Ratio (OR) = 0.44(0.18, 1.06); p = 0.068].

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The multivariate model suggests that patients with increased levels of post-NAC CAMLs were at increased odds of achieving pCR [OR = 1.490 (1.017, 2.182); p = 0.042], while CTCs showed a trend in negatively predicting pCR [OR = 0.439 (0.182, 1.062); p = 0.068] ( Figure 3 ).

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Whereas the median total number of CTCs before NAC was lower [median = 1 (IQR = 3.5)] in the pCR group compared with the non-pCR group [median = 5 (IQR = 5.750)], it did not reach statistical significance ( p = 0.096).

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Overall, the CAMLs showed an increasing trend in the pCR group as the treatment progressed. 3.4.

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