The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.

Mol Neurodegener · 2023 · PMC10537207 · PMID 37759260

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.1200

boldest claim

The sentences

a clear trendp = 0.07so close (0.05 < p ≤ 0.1)

Mean spike frequency averaged over a 24 h period showed a clear trend towards increased number of spikes in the J20 and Gria2 G/G /J20 mice, though this was not statistically significant (ANOVA; F (3,15) = 2.9 p = 0.07; Fig. 3 b).

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showed a trendp = 0.12not close (p > 0.1)

(e) The ratio of open arm to total arm entries in the elevated plus maze showed a trend towards more open arm entries in J20 animals and a recovery of this in GluA2 G/G /J20 mice (Welch’s ANOVA W (3,29.15) = 2.12, p = 0.12; n’s : WT = 15, GluA2 G/G = 13, J20 = 16, GluA2 G/G /J20 = 14).

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a strong trendno p-value reported

Here, we found J20 mice have a strong trend toward increased open arm entries as a ratio of total arm entries in the EPM, similar to what we have previously observed in this model [ 65 ].

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