Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome.

Positive IGFBP-3 expression showed a possible trend in association with increased proliferation ( P = 0.096), oestrogen receptor (ER) negativity ( P = 0.06) and HER-2 overexpression ( P = 0.065) in invasive tumours and a strong association with ER negativity ( P = 0.037) in DCIS.

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2 ) demonstrate a possible trend towards a more favourable outcome for IGFBP-3-negative tumours, although this failed to reach statistical significance for OS ( P = 0.168) or DFS ( P = 0.269), perhaps related in part to the small numbers of IGFBP-3-negative tumours observed in this study.

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Although IGFBP-3 expression was not an independent prognosticator, IGFBP-3-positive breast cancers may have shorter disease-free and overall survivals, although these did not reach statistical significance.

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Increasing levels of IGFBP-3 expression showed a trend with increased proliferation, oestrogen receptor (ER) negativity and HER-2 overexpression to suggest its association with poor prognostic tumours.

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