Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo.

1 c), with a strong trend for an increased neutrophil frequency compared to G1 Tert −/− mice (Fig. 1 d).

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4 f, results did not reach statistical significance).

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Pro-inflammatory cytokines, such as IL-6, MCP-1, and TNF-α, as well as IL-1β (known to promote myeloid differentiation [ 49 ]) and the anti-inflammatory cytokine, IL-10, were elevated in G3 compared to G1 Tert −/− recipients, but showed a trend for decreased expression with NR supplementation (Fig. 4 b, Supplementary Table 1).

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