Proceedings to the 61<sup>st</sup> Annual Conference of the Particle Therapy Cooperative Group: 10 June - 16 June, 2023 Co-organized by the Quironsalud and the Clinica Universidad de Navarra, Madrid, Spain.

Abdominal compression resulted to be highly significant as well (p <0.01).

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A significant trend towards better local control in hypoFx patients could be observed (overall LC 58.2% for nFx vs 90.5% for hypoFx, HR = 0.15, 95%CI: 0.02-0.86, p = 0.034) and high-dose PTV volume > 60 cm3 was a significant risk factor for locoregional progression (Figure 1). 11 patients (28.9%) developed ≥ G3 serious late complications, mostly soft tissue necrosis and infections which eventually improved in 6 of them.

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Patients with lymphopenia showed a trend towards poorer progression-free survival (p=0.06).

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Results : In the patient group without OAR monitoring, a clear trend in heart dose was observed during treatment course, with an average increase in MHD of 0.5 Gy/wk (confidence interval (CI): [0.3,0.7] Gy/wk), while the group with OAR monitoring experienced an average MHD increase of 0.1 (CI: [-0.1,0.3]) Gy/wk (p<0.05).

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