Immunogenicity of PE18, PE31, and PPE26 proteins from <i>Mycobacterium tuberculosis</i> in humans and mice.

As for the BCG-vaccinated control and the ATB groups, differences were also found with individuals exhibiting a higher PE31 titre, although this did not reach statistical significance.

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There were no significant differences in their immunoreactivity between the three population groups, except for PE31, which showed a trend toward higher immunoreactivity with BCG-vaccinated healthy individuals compared to patients with TB, although this difference was not statistically significant ( p=0.0863 ) ( Figure 2A ).

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We also observed a clear trend of highest production of these cytokines in PBMC from LTBI donors, though this did not reach statistical significance due to a small sample size (n=12).

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