PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma.

At the higher doses of 1000 nM and 3000 nM, RGS caused a 3.4- and 3.3-fold increase in caspase 3/7 activity ( P < 0.01), with a clear trend towards an increase at 300 nM ( Fig. 4B ).

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When compared to ACA and NAG, PLK1 staining showed a trend of increased expression in ACC, even if this did not reach statistical significance ( Fig. 2B ).

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