In individuals with type 1 diabetes mellitus, significant differences were observed in the expression of miR-378a ( p = 0.000) and miR-122 ( p = 0.019), and a strong trend in miR-142 ( p = 0.075), which all showed lower expression compared to the healthy control group.
Several miRNA, including miR-155, miR-30e, miR-378a, miR-15a, miR-16, miR-26b, miR-106, miR-126, miR-328, and miR-877, showed a trend towards lower expression associated with overweight and/or adipositas groups.
The analysis revealed a significant lower expression of miR-155 in persons with mild metabolic disorders ( p = 0.047), while other trends were observed but did not reach statistical significance.