Oncolytic Tanapoxvirus Variants Expressing mIL-2 and mCCL-2 Regress Human Pancreatic Cancer Xenografts in Nude Mice.

Likewise, the results for immune reconstituted study groups also failed to demonstrate a clear trend when compared between baseline to post-virotherapy samples or when compared between study groups.

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While [ 18 F]-FLT TLP data did not reach statistical significance for any study group, the trends observed demonstrate that group mean [ 18 F]-FLT TLP signal intensity levels correlate well with final group mean tumor volumes and histopathology results.

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While TPV/eGFP and TPV/∆66R/m-IL-2/mCherry demonstrated a trend of regressed tumor volume over the course of the study, both recombinants failed to reach statistical significance ( Figure 1 A,B).

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