Regulation of muscle pyruvate dehydrogenase activity and fuel use during exercise in high-altitude deer mice.

We found that V̇ O 2 ,max did not differ between testing altitudes ( F 1,13 =2.243, P =0.158), nor did the average speed at which highland mice reached V̇ O 2 ,max ( P >0.05) or 75% V̇ O 2 ,max , although it approached significance ( P =0.050; Table 1 ).

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However, this trend failed to reach statistical significance ( F 2,15 =1.53, P =0.249).

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PDHa showed a trend to increase from normoxia-acclimated mice (0.713±0.163 mmol kg −1 min −1 ) to hypoxia-acclimated mice (1.032±0.205 mmol kg −1 min −1 ) and to wild highlanders (1.166±0.179 mmol kg −1 min −1 ).

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