Oral Fecal Microbiota Transplantation in Dogs with Tylosin-Responsive Enteropathy-A Proof-of-Concept Study.

Dogs that received the placebo treatment were statistically different from the healthy dogs at all visit time points, except the post-treatment visit, although in this case, this comparison showed a trend ( p = 0.05).

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After receiving FMT in the treatment visit, the alpha diversity of the fecal microbiome in TRE dogs increased compared to the screening visit, although the p -value hovered around significance (Shannon index: treatment visit versus screening visit, p = 0.073), but the same trend was not observed between dogs at the endoscopy visit and at the treatment visit (treatment visit versus endoscopy visit, p = 0.128).

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After FMT treatment, there was a trend towards increased alpha diversity in TRE dogs at the treatment visit compared to the screening visit, which suggests that FMT may help in partially restoring microbial diversity in TRE dogs, although this increase did not reach statistical significance.

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Interestingly, the placebo group also exhibited significant differences in beta diversity compared to healthy dogs, except at the post-treatment visit, where a trend towards significance was observed.

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