Type 2 Cytokine-Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study.

JID Innov · 2025 · PMC11460444 · PMID 39385749

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a clear trendno p-value reported

did not reach statistical significanceno p-value reported

IL-4/IL-13–mediated decrease in gene expression of the late differentiation markers filaggrin and loricrin did not reach statistical significance, although a clear trend of reduction was visible ( Figure 5 e and f).

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showed a trendno p-value reported

Similarly as seen for filaggrin, IL-4/IL-13 showed a trend in reduction of loricrin gene expression.

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