Expression of interferon-stimulated genes, but not polymorphisms in the interferon α/β receptor 2 gene, is associated with coronavirus disease 2019 mortality.

19 %); however, it did not reach statistical significance.

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We found a strong trend of increased IFIT1 and CH25H expressions in non-survived patients with P values of approximately 0.07–0.08 ( Fig. 2 A and B).

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We found no correlation between the IFNAR2 polymorphism and the survival of patients with COVID-19; however, the data showed a trend of higher frequencies of the A allele and AA genotype in non-survived compared to survived patients, although the difference did not reach statistical significance. 3.6 IFNAR2 rs2236757 polymorphism did not affect ISGs expression To understand whether the rs2236757 genetic variant affects the expression of ISGs in the setting of COVID-19, we analyzed the expression of the six ISGs according to rs2236757.

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