Glycemic indicators and mental health symptoms: results from the greater Beirut area cardiovascular cohort.

Glycemic indicators and depressive and anxiety symptoms Unadjusted linear regression analyses ( Table 3 ) showed that baseline glycemic indicators were related to both mental health outcomes: higher baseline FBG levels were associated with higher depressive and anxiety symptoms (beta=0.024, 95% CI= [-0.002, 0.051], p-value=0.072 and beta=0.035, 95% CI= [0.009, 0.060], p-value=0.009, respectively); higher baseline HbA1c levels also showed a trend of positive association with depressive symptoms but without reaching statistical significance (beta=0.532, 95% CI = [-0.158, 1.223], p-value=0.130).

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The FBG plots ( Figure 1 ) suggest a change in the association, wherein a positive association is observed in the range of FBG>126 whereas below 126 associations have a negative trend, and this is observed for both baseline and follow-up FBG values and for both depression and anxiety symptoms.

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We note that patterns of associations were consistent at both baseline and follow-up and that HbA1c 5-year follow-up values in the non-diabetic range showed close to significance associations.

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With regards to HbA1c, there was a similar trend for baseline HbA1c levels, with negative associations with mental health symptoms in the below 6.5 range and positive association in the ≥6.5 range; however, they did not reach statistical significance.

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