Transcriptomic analysis reveals a critical role for activating G_sα mutations in spontaneous feline hyperthyroidism.

However, a predicted alternative iodide transporter SLC26A10 showed significantly increased expression in HT thyroids, along with another transporter SLC26A7 , known to contribute to iodide efflux from thyrocytes 30 , which showed a trend towards higher expression (Fig.

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In addition, the gene encoding thyroglobulin, TG , was more highly expressed in the majority of HT samples but was only nominally significant in the differential gene expression analysis (Fig.

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There was a clear trend in normalised expression levels for genes in each cluster relative to histopathological grade (Fig. 2 d).

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