Ribitol and ribose treatments differentially affect metabolism of muscle tissue in FKRP mutant mice.

The Level of 5’-IMP was increased by both treatments, approaching significance in ribose-treated samples (0.05 < p < 0.1).

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However, 5 metabolites (glutamate, hypotaurine, 5-aminovalerate, methionine and S-methylmethionine) were significantly increased (or approached significance) by both treatments, while 1-methylhistidine was downregulated with both treatments (Fig. 4 ).

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Effect of ribitol and ribose treatment on tricarboxylic acid cycle (TCA) The level of citrate was clearly upregulated by both treatments, although the increase by ribose treatment barely missed statistical significance (Fig. 3 ).

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