Barely Significant
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The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development.

EMBO Rep · 2025 · PMC11724065 · PMID 39578553

Europe PMCDOI
3
hedged sentences
0.0700
closest p · 1.4× alpha
0.0700
boldest claim

The sentences

reached borderline significanceP ≤ 0.07so close (0.05 < p ≤ 0.1)
QPCR showed a trend of reduced Slc46a1 transcript levels in KO compared to WT antNPCs that reached borderline significance ( P ≤ 0.07), supported by a Western blot analysis that revealed notable loss in PCFT protein expression in Tet1 KO cells (Fig. 6C,D ).

also in 93 other papers

showed a trendP ≤ 0.07so close (0.05 < p ≤ 0.1)
QPCR showed a trend of reduced Slc46a1 transcript levels in KO compared to WT antNPCs that reached borderline significance ( P ≤ 0.07), supported by a Western blot analysis that revealed notable loss in PCFT protein expression in Tet1 KO cells (Fig. 6C,D ).

also in 22,539 other papers

did not reach statistical significanceno p-value reported
Direct FA injection did not reduce NTD rates in CD1- Tet1 KO embryos compared to controls and might even slightly exacerbate NTD penetrance to as high as 85%, although the difference did not reach statistical significance (Fig. 1G ).

also in 50,127 other papers

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