Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy.

Although cinobufagin slightly increased the proportion of BrMs relative to that of MdMs, this change did not reach statistical significance (Fig. 10 J).

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Furthermore, patients with high PANoScores presented a clear trend toward longer progression-free survival (PFS) and overall survival (OS) compared to those with low PANoScores (Fig. 7 J-O).

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We subsequently utilized four clinical immunotherapy cohorts (PRJNA482620, PRJEB23709, GSE91061 , and GSE35640 ) for validation, revealing a significant trend toward higher PANoScore in responders than in nonresponders (Fig. 7 F-I).

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