Endometriosis Severity and Risk of Preeclampsia: A Combined Mendelian Randomization and Observational Study.

Int J Womens Health · 2025 · PMC11956705 · PMID 40165857

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0950

boldest claim

The sentences

approached significancep = 0.051so close (0.05 < p ≤ 0.1)

Other methods, such as the MR Egger and Weighted Median, showed no statistically significant results, although the Weighted Median method approached significance (p = 0.051, OR = 1.0003, 95% CI = 1.0000–1.0005).

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borderline non-significantp = 0.056so close (0.05 < p ≤ 0.1)

Below are the key findings from the MR results, categorized by method and exposure type ( Figure 1 ). For overall endometriosis, the Inverse Variance Weighted (IVW) method demonstrated a borderline non-significant association with PE or eclampsia (p = 0.056, OR = 1.0002, 95% CI = 1.0000–1.0005).

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did not reach statistical significancep = 0.094so close (0.05 < p ≤ 0.1)

Regarding ovarian combined with peritoneal endometriosis, although there was a higher percentage in the GHD group (82%), the difference across the three groups did not reach statistical significance (p = 0.094).

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a trend towards significancep = 0.095so close (0.05 < p ≤ 0.1)

CA199 levels showed a trend towards significance (p = 0.095), with higher median values in the GHD group (62.64) compared to the non-hypertension group (32.28).

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showed a trendp = 0.095so close (0.05 < p ≤ 0.1)

CA199 levels showed a trend towards significance (p = 0.095), with higher median values in the GHD group (62.64) compared to the non-hypertension group (32.28).

also in 15,197 other papers

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