Radioiodine Exhalation Following Oral I-131 Administration in a Mouse Model.

However, when comparing either of these fractions with the organically bound I-131 fraction, highly significant differences emerged ( p < 0.0001 for both aerosol vs. organically bound I-131 and I 2 vs. organically bound I-131).

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The effect of carbimazole was borderline significant compared to the control group ( p = 0.052), whereas the effect of L-thyroxine was highly significant ( p < 0.0001).

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The 1 mg KI premedication showed a near-significant trend ( p = 0.0536).

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L-thyroxine also exhibited a tendency toward reducing exhaled radioiodine activity, though this effect did not reach statistical significance.

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This figure reveals a clear trend following the oral administration of 0.1 MBq and 10 MBq of I-131: as potassium iodide (KI) doses increase, the proportion of organically bound I-131 decreases, while the proportion of elemental iodine (I 2 ) increases.

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