Meta-analysis did show a trend in failure rate favoring xenografts in more recent studies (less failures); however, it failed to reach statistical significance with an OR of 0.48 (95% CI 0.08, 2.90), P = .42 ( Fig. 2 ).
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Efficacy and safety of xenograft augmentation in rotator cuff repair: a systematic review and meta-analysis.
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The findings from the meta-analysis of RCTs suggest lower failure rates and higher radiological healing rates with xenograft augmentation, though these differences did not reach statistical significance.
The included individual studies showed a trend towards a higher complication rate in the xenograft cohort; however, none of them showed a statistically significantly higher rate.