Prognostic Value of D-Dimer in Acute Type A Aortic Dissection and Intramural Hematoma: Observations from the Acute Aortic Syndrome Group of the Registry of Acute Non-Traumatic Chest Pain in China.

Additionally, patients in the highest D‐dimer quartile (Q4) exhibited a significantly higher HR for in‐hospital mortality compared with those in the lowest D‐dimer quartile (Q1) (HR, 1.47 [95% CI, 1.13–1.92]), and higher baseline D‐dimer was associated with a significant trend toward higher in‐hospital mortality in patients ( P trend < 0.001; Table 3 ).

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However, the increasing risk trend did not reach statistical significance ( P for trend >0.050).The highest D‐dimer quartile (Q4) did not significantly associate with overall (HR, 2.61 [95% CI 0.70–9.73]) or in‐hospital mortality (HR, 1.78 [95% CI 0.44–7.24]) of patients with AIMH by multivariable adjustment in model 3 (Table 3 ).

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In conservatively treated patients, higher D‐dimer levels showed a trend toward increased mortality, though no statistically significant association with overall or in‐hospital mortality was observed.

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