Down-regulation of neuroprotective protein kinase D in Huntington´s disease.

Notably, while AxV binding tended to be higher in neurons pretreated with CRT compared to those treated with NMDA alone, this difference did not reach statistical significance ( P = 0.07) (Fig. 5B ).

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Contrary to expectations, analysis by qRT-PCR of PRKD1 mRNA content in the striatum and cortex of HD patients and control subjects showed a trend towards an increase in HD striatum, with a significant upregulation of PRKD1 transcripts observed in HD cortex (Fig. 1D ).

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In contrast, NMDA treatment induced a highly significant increase in AxV binding, with the most pronounced and statistically significant effects observed at the earliest time point (30 min) following NMDA stimulation (Fig. 5B ).

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In contrast to these findings, we observed a substantial reduction in PKD protein levels in the striatum, the primarily affected brain structure in HD, with a clear trend toward decreased levels in the cerebral cortex of HD patients.

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