Skeletal Muscle Density as a Predictive Marker for Pathologic Complete Response in Triple-Negative Breast Cancer Treated with Neoadjuvant Chemoimmunotherapy.

Additionally, the BMI was lower in the high-SMD group but did not reach statistical significance (23.26 vs. 24.62, p = 0.068).

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Similarly, the CPS-based stratification showed a significant trend, with the highest pCR rates observed in the high-CPS group, followed by the medium- and low-CPS groups (χ 2 for trend, p = 0.011).

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The fact that the SMD’s odds ratio and statistical significance for a pCR were similar to those of the CPS, along with a clear trend when categorized into tertiles, suggests that SMD may serve as a predictive marker for pCR from a host factor perspective.

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