The Prognostic Value of Tumor Fibrosis in Patients Undergoing Hepatic Metastasectomy for Colorectal Cancer: A Retrospective Pooled Analysis.

Cancers (Basel) · 2025 · PMC12153617 · PMID 40507350

Europe PMC DOI

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closest p

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showed a trendno p-value reported

Overall survival in the entire cohort showed a trend favoring patients with tumor fibrosis > 40% (median survival = 51 months, 95% CI: 20.90–81.09) compared to those with fibrosis < 40% (median survival = 30 months, 95% CI: 22.83–37.16); log-rank test p = 0.036.

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did not reach statistical significancep = 0.076so close (0.05 < p ≤ 0.1)

approaching significanceno p-value reported

Primary tumor location did not reach statistical significance in the multivariate model (OR = 4.607 for left-sided tumors, 95% CI: 0.854–24.855; p = 0.076), but it was retained due to potential clinical relevance, small sample size, and a p -value approaching significance.

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