Heart Failure, Kidney Function, and Elderly Age, Rather than Levofloxacin Therapy, Are Associated with QTc Prolongation in COVID-19 Patients.

J Clin Med · 2025 · PMC12156308 · PMID 40507768

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a near-significant trendno p-value reported

There was a near-significant trend observed in the relationship between COVID-19 severity and QTc prolongation, with patients who experienced moderate to severe COVID-19 course (median QTc 430 ms) compared to those with mild disease (median QTc 400 ms) ( p = 0.054).

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did not reach statistical significanceno p-value reported

Univariate Analysis The receiving of levofloxacin, which was identified as a substance potentially affecting myocardial depolarization and repolarization, in our study did not reach statistical significance for its effect on QT interval.

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approaching significanceno p-value reported

We confirmed that heart rate (HR) demonstrated a negative correlation with QTc (Rho = −0.18, p = 0.078), approaching significance.

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