Prevalence of Impaired Bone Health in Premature Ovarian Insufficiency and Early Menopause and the Impact of Time to Diagnosis.

J Clin Med · 2025 · PMC12194335 · PMID 40565957

Europe PMC DOI

hedged sentences

0.0220

closest p · 0.4× alpha

0.1080

boldest claim

The sentences

a negative trendp = 0.022actually significant

A negative trend observed in the scatter plot suggests a clear association between time to diagnosis and lumbar L1–L4 BMD (r = −0.255, p = 0.022) as well as T-score (r = −0.21, p = 0.031; Figure 4 ).

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did not reach statistical significancep = 0.108not close (p > 0.1)

Overall, 17.5% (14/80) of the POI patients were affected compared to 6.7% (3/45) in the EM group; however, this difference did not reach statistical significance based on Fisher’s exact test ( p = 0.108).

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a clear trendno p-value reported

The distribution of bone mineral density status in relation to time to diagnosis revealed a clear trend: among the patients diagnosed within 6 months of symptom onset, 18 (45.0%) had normal bone density, 18 (45.0%) had osteopenia, and only 3 (7.5%) were osteoporotic.

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