Do Pain and Autonomic Regulation Share a Common Central Compensatory Pathway? A Meta-Analysis of HRV Metrics in Pain Trials.

NeuroSci · 2025 · PMC12285944 · PMID 40700127

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0990

boldest claim

The sentences

showed a trendp = 0.059so close (0.05 < p ≤ 0.1)

Meta-analysis of time-domain HRV parameters showed a trend toward improvement: SDNN (g = 0.435, p = 0.059) approached significance, while RMSSD (g = 0.361, p = 0.099) and pNN50 (g = 0.222, p = 0.548) showed smaller, non-significant effects.

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approaching significancep = 0.07so close (0.05 < p ≤ 0.1)

SDNN analysis (7 studies, n = 311) demonstrated a moderate positive effect approaching significance (Hedges’ g = 0.44, 95% CI [−0.04, 0.91], p = 0.07) with considerable heterogeneity (I 2 = 71.2%).

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approached significancep = 0.099so close (0.05 < p ≤ 0.1)

Meta-analysis of time-domain HRV parameters showed a trend toward improvement: SDNN (g = 0.435, p = 0.059) approached significance, while RMSSD (g = 0.361, p = 0.099) and pNN50 (g = 0.222, p = 0.548) showed smaller, non-significant effects.

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trend toward significanceno p-value reported

While all three parameters showed positive effect sizes, none reached statistical significance at the conventional p < 0.05 level, with SDNN showing the strongest trend toward significance.

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